Human MT3 Recombinant Protein (RPPB4017)
- SKU:
- RPPB4017
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P25713
Description
| Product Name: | Human MT3 Recombinant Protein |
| Product Code: | RPPB4017 |
| Size: | 10µg |
| Species: | Human |
| Target: | MT3 |
| Synonyms: | GIF, GIFB, GRIF, ZnMT3, Metallothionein-3, MT-3, Growth inhibitory factor, Metallothionein-III, MT-III, MT3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The MT3 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMDPETCP CPSGGSCTCA DSCKCEGCKC TSCKKSCCSC CPAECEKCAK DCVCKGGEAA EAEAEKCSCC Q |
Metallothionein 3 (MT3) contains 3 zinc and 3 copper atoms per polypeptide chain and a minor amount of cadmium. MT3 inhibits survival and neurite formation of cortical neurons in vitro. MT3 also binds heavy metals.��
MT3 Human Recombinant produced in E. coli is a single polypeptide chain containing 91 amino acids (1-68) and having a molecular mass of 9.3kDa (molecular size on SDS-PAGE will appear higher).MT3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | MT3: Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro. Belongs to the metallothionein superfamily. Type 1 family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 16q13 Cellular Component: synaptic vesicle; perinuclear region of cytoplasm; cytoplasm; inclusion body; intracellular Molecular Function:antioxidant activity; protein binding; copper ion binding; zinc ion binding; caspase inhibitor activity; drug binding; cadmium ion binding; protein kinase activator activity Biological Process: positive regulation of catalytic activity; negative regulation of autophagy; removal of superoxide radicals; positive regulation of transcription, DNA-dependent; negative regulation of axon extension; negative regulation of caspase activity; positive regulation of vascular endothelial growth factor receptor signaling pathway; zinc ion homeostasis; cadmium ion homeostasis; cellular lipid catabolic process; histone modification; protein kinase B signaling cascade; negative regulation of neuron apoptosis; cholesterol catabolic process; regulation of response to food; protein stabilization; cellular zinc ion homeostasis; activation of protein kinase B; zinc ion transport; regulation of protein amino acid glycosylation; astrocyte development; leptin-mediated signaling pathway; cell proliferation; cellular metal ion homeostasis; protein import into nucleus, translocation; negative regulation of oxidoreductase activity; response to hypoxia; energy reserve metabolic process; positive regulation of protein amino acid phosphorylation; negative regulation of cell growth; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis |
| UniProt Code: | P25713 |
| NCBI GenInfo Identifier: | 5174762 |
| NCBI Gene ID: | 4504 |
| NCBI Accession: | NP_005945.1 |
| UniProt Secondary Accession: | P25713,Q2V574, |
| UniProt Related Accession: | P25713 |
| Molecular Weight: | 6,927 Da |
| NCBI Full Name: | metallothionein-3 |
| NCBI Synonym Full Names: | metallothionein 3 |
| NCBI Official Symbol: | MT3�� |
| NCBI Official Synonym Symbols: | GIF; GIFB; GRIF; ZnMT3�� |
| NCBI Protein Information: | metallothionein-3; MT-3; MT-III; metallothionein-III; growth inhibitory factor; metallothionein 3 (growth inhibitory factor (neurotrophic)) |
| UniProt Protein Name: | Metallothionein-3 |
| UniProt Synonym Protein Names: | GIFB; GIF; Growth inhibitory factor; Metallothionein-III |
| Protein Family: | Metallothionein |
| UniProt Gene Name: | MT3�� |
| UniProt Entry Name: | MT3_HUMAN |
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