Enzymes Recombinant Proteins

Human MSRB3 Recombinant Protein (RPPB1982)

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RPPB1982

Description

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Product Name:Human MSRB3 Recombinant Protein
Product Code:RPPB1982
Size:10µg
Species:Human
Target:MSRB3
Synonyms:Methionine-R-sulfoxide reductase B3, MSRB3, DFNB74, FLJ36866, DKFZp686C1178.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The MSRB3 solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 10% glycerol and 0.1mM PMSF.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MCGLPSGSCR DKKNCKVVFS QQELRKRLTP LQYHVTQEKG TESAFEGEYT HHKDPGIYKC VVCGTPLFKS ETKFDSGSGW PSFHDVINSE AITFTDDFSY GMHRVETSCS QCGAHLGHIF DDGPRPTGKR YCINSAALSF TPADSSGTAE GGSGVASPAQ ADKAELLEHH HHHH

Methionine sulfoxide reductase B3 (MSRB3) is a member of the methionine sulfoxide reductases (MSR) family proteins. MSRB3 catalyzes the reduction of methionine sulfoxide to methionine. The MSRB3 enzyme acts as a monomer and requires zinc as a cofactor. MSRs are thought to defend against reactive oxygen species-induced oxidative damage in various organs, including the most environmentally exposed organ, the human skin. MSRB3 has a vital role in cold tolerance by eliminating MetO and ROS which accumulate at the ER during cold acclimation.

MSRB3 Human Recombinant fused with an�8 amino acid His tag at C-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing�174 amino acids (21-185 a.a.) and having a molecular mass of 19kDa. The MSRB3 is purified by proprietary chromatographic techniques.

UniProt Protein Function:Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing.
NCBI Summary:The protein encoded by this gene catalyzes the reduction of methionine sulfoxide to methionine. This enzyme acts as a monomer and requires zinc as a cofactor. Several transcript variants encoding two different isoforms have been found for this gene. One of the isoforms localizes to mitochondria while the other localizes to endoplasmic reticula. [provided by RefSeq, Jul 2010]
UniProt Code:Q8IXL7
NCBI GenInfo Identifier:73089054
NCBI Gene ID:253827
NCBI Accession:NP_001026849.1
UniProt Secondary Accession:Q8IXL7,Q6UXS2, B4DR19, B7ZAQ0,
UniProt Related Accession:Q8IXL7
Molecular Weight:20,010 Da
NCBI Full Name:methionine-R-sulfoxide reductase B3 isoform 2
NCBI Synonym Full Names:methionine sulfoxide reductase B3
NCBI Official Symbol:MSRB3��
NCBI Official Synonym Symbols:DFNB74��
NCBI Protein Information:methionine-R-sulfoxide reductase B3
UniProt Protein Name:Methionine-R-sulfoxide reductase B3
Protein Family:Methionine-R-sulfoxide reductase
UniProt Gene Name:MSRB3��
UniProt Entry Name:MSRB3_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q8IXL7
Research Area:
Enzymes
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