Human MSI2 Recombinant Protein (RPPB4011)

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SKU:
RPPB4011
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q96DH6

Description

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Product Name:Human MSI2 Recombinant Protein
Product Code:RPPB4011
Size:10µg
Species:Human
Target:MSI2
Synonyms:MSI2H, RNA-binding protein Musashi homolog 2, Musashi-2, MSI2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The MSI2 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMEANGSQ GTSGSANDSQ HDPGKMFIGG LSWQTSPDSL RDYFSKFGEI RECMVMRDPT TKRSRGFGFV TFADPASVDK VLGQPHHELD SKTIDPKVAF PRRAQPKMVT RTKKIFVGGL SANTVVEDVK QYFEQFGKVE DAMLMFDKTT NRHRGFGFVT FENEDVVEKV CEIHFHEINN KMVECKKAQP KEVMFPPGTR GRARGLPYTM DAFMLGMGML GYPNFVATYG RGYPGFAPSY GYQFPGFPAA AYGPVAAAAV AAARGSGSNP ARPGGFPGAN SPGPVADLYG PASQDSGVGN YISAASPQPG SGFGHGIAGP LIATAFTNGY H

Musashi RNA-Binding Protein 2 (MSI2), is RNA binding protein which owns 2 conserved tandem RNA recognition motifs. MSI2 takes part in proliferation and maintenance of stem cells in the central nervous system. Comparable proteins in other species function as RNA-binding proteins and take part in posttranscriptional gene regulation.

MSI2 Human Recombinant produced in E. coli is a single polypeptide chain containing 351 amino acids (1-328) and having a molecular mass of 37.6kDa. MSI2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Musashi-2: RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system. Chromosomal aberrations involving MSI2 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with HOXA9; translocation t(7;17)(q32-34;q23). Belongs to the Musashi family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: RNA-bindingChromosomal Location of Human Ortholog: 17q22Cellular Component: polysome; cytoplasmMolecular Function: nucleotide binding; poly(U) bindingBiological Process: stem cell development
UniProt Protein Details:
NCBI Summary:This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q96DH6
NCBI GenInfo Identifier:20373175
NCBI Gene ID:124540
NCBI Accession:EAW94506
UniProt Secondary Accession:Q96DH6,Q7Z6M7, Q8N9T4
UniProt Related Accession:Q96DH6
Molecular Weight:
NCBI Full Name:RNA-binding protein Musashi homolog 2 isoform a
NCBI Synonym Full Names:musashi RNA-binding protein 2
NCBI Official Symbol:MSI2��
NCBI Official Synonym Symbols:MSI2H��
NCBI Protein Information:RNA-binding protein Musashi homolog 2; musashi-2; musashi homolog 2
UniProt Protein Name:RNA-binding protein Musashi homolog 2
UniProt Synonym Protein Names:
Protein Family:RNA-binding protein
UniProt Gene Name:MSI2��
UniProt Entry Name:MSI2H_HUMAN
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