Human MRPS23 Recombinant Protein (RPPB4007)

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SKU:
RPPB4007
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9Y3D9

Description

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Product Name:Human MRPS23 Recombinant Protein
Product Code:RPPB4007
Size:20µg
Species:Human
Target:MRPS23
Synonyms:Mitochondrial Ribosomal Protein S23, MRP-S23, S23mt, 28S Ribosomal Protein S23, Mitochondrial, CGI-138, HSPC329, MRPS23.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:MRPS23 protein solution (1mg/ml) containing Phosphate buffer saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMAGSRLE TVGSIFSRTR DLVRAGVLKE KPLWFDVYDA FPPLREPVFQ RPRVRYGKAK APIQDIWYHE DRIRAKFYSV YGSGQRAFDL FNPNFKSTCQ RFVEKYTELQ KLGETDEEKL FVETGKALLA EGVILRRVGE ARTQHGGSHV SRKSEHLSVR PQTALEENET QKEVPQDQHL EAPADQSKGL LPP

Mitochondrial Ribosomal Protein S23, also known as MRPS23 belongs to the mammalian mitochondrial ribosomal proteins which are encoded by nuclear genes and assist in protein synthesis inside the mitochondrion. Mitochondrial ribosomes consist of a small 28S subunit and a large 39S subunit. In addition, they have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. An additional difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Between different species, the proteins containing the mitoribosome differ very much in sequence, �and occasionally in biochemical properties, which prevents easy recognition by sequence homology.

MRPS23 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 213 amino acids (1-190 a.a) and having a molecular mass of 24.2kDa.MRPS23 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:MRPS23: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
UniProt Protein Details:

Protein type:Translation; Mitochondrial; Ribosomal

Chromosomal Location of Human Ortholog: 17q22-q23

Cellular Component: intermediate filament cytoskeleton; mitochondrial inner membrane; mitochondrion; nuclear membrane

Molecular Function:protein binding

NCBI Summary:Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 7p. [provided by RefSeq, Jul 2008]
UniProt Code:Q9Y3D9
NCBI GenInfo Identifier:31077184
NCBI Gene ID:51649
NCBI Accession:Q9Y3D9.2
UniProt Secondary Accession:Q9Y3D9,Q96Q24, Q9BWH8, Q9P053, B2R6V3,
UniProt Related Accession:Q9Y3D9
Molecular Weight:21,771 Da
NCBI Full Name:28S ribosomal protein S23, mitochondrial
NCBI Synonym Full Names:mitochondrial ribosomal protein S23
NCBI Official Symbol:MRPS23��
NCBI Official Synonym Symbols:CGI-138; HSPC329; MRP-S23��
NCBI Protein Information:28S ribosomal protein S23, mitochondrial
UniProt Protein Name:28S ribosomal protein S23, mitochondrial
Protein Family:28S ribosomal protein
UniProt Gene Name:MRPS23��
UniProt Entry Name:RT23_HUMAN
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