Human MRPL48 Recombinant Protein (RPPB4005)

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SKU:
RPPB4005
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q96GC5

Description

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Product Name:Human MRPL48 Recombinant Protein
Product Code:RPPB4005
Size:20µg
Species:Human
Target:MRPL48
Synonyms:Mitochondrial Ribosomal Protein L48, MRP-L48, L48MT, 39SRibosomal Protein L48, Mitochondrial, CGI-118, HSPC290, 39S ribosomal proteinL48, mitochondrial.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:MRPL48 protein solution (1 mg/ml) containing 20mMTris-HCl buffer (pH 8.0) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSSGEKPIY SVGGILLSIS RPYKTKPTHG IGKYKHLIKA EEPKKKKGKVEVRAINLGTD YEYGVLNIHL TAYDMTLAES YAQYVHNLCN SLSIKVEESY AMPTKTIEVL QLQDQGSKMLLDSVLTTHER VVQISGLSAT FAEIFLEIIQ SSLPEGVRLSVKEHTEEDFK GRFKARPELE ELLAKLK

Mitochondrial Ribosomal Protein L48, also known as MRPL48, is amammalian mitochondrial ribosomal protein which assists in protein synthesiswithin the mitochondrion. Mitochondrial ribosomes, mitoribosomes, consist of asmall 28S subunit and a large 39S subunit. They include an estimated 75%protein to rRNA composition while comparing to prokaryotic ribosomes, wherethis ratio is reversed.An additional dissimilarity between mammalian mitoribosomes & prokaryoticribosomes is that the latter contain a 5S rRNA. Between different species, theproteins containing the mitoribosome differ very much in sequence, as well as inbiochemical properties from time to time, which prevents easy recognition throughsequence homology. MRPL48 encodes a 39S subunit protein. A pseudogenecorresponding to MRPL48 is found on chromosome 6p.

MRPL48 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 207 amino acids (29-212 a.a) andhaving a molecular mass of 23.1kDa.MRPL48 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:MRPL48: Interacts with OXA1L.
UniProt Protein Details:

Protein type:Mitochondrial

Chromosomal Location of Human Ortholog: 11q13.4

Cellular Component: mitochondrial inner membrane; mitochondrial ribosome

Molecular Function:protein binding

NCBI Summary:Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 6p. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]
UniProt Code:Q96GC5
NCBI GenInfo Identifier:118573683
NCBI Gene ID:51642
NCBI Accession:Q96GC5.2
UniProt Secondary Accession:Q96GC5,Q49AK7, Q4U2Q4, Q9P091, Q9Y5J0, B4DN34,
UniProt Related Accession:Q96GC5
Molecular Weight:21,749 Da
NCBI Full Name:39S ribosomal protein L48, mitochondrial
NCBI Synonym Full Names:mitochondrial ribosomal protein L48
NCBI Official Symbol:MRPL48��
NCBI Official Synonym Symbols:L48MT; CGI-118; HSPC290; MRP-L48��
NCBI Protein Information:39S ribosomal protein L48, mitochondrial
UniProt Protein Name:39S ribosomal protein L48, mitochondrial
Protein Family:39S ribosomal protein
UniProt Gene Name:MRPL48��
UniProt Entry Name:RM48_HUMAN
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