Human MRPL2 Recombinant Protein (RPPB4002)
- SKU:
- RPPB4002
Description
| Product Name: | Human MRPL2 Recombinant Protein |
| Product Code: | RPPB4002 |
| Size: | 20µg |
| Species: | Human |
| Target: | MRPL2 |
| Synonyms: | 39S ribosomal protein L2, mitochondrial , CGI-22,MRP-L14, RPML14, L2mt, MRP-L2, CGI-22. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | MRPL2 protein solution (0.25mg/ml) containing 20mMPhosphate buffer (pH 8.0), 1mM EDTA, 50% glycerol and 2mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSGRDHTGR IRVHGIGGGH KQRYRMIDFL RFRPEETKSG PFEEKVIQVRYDPCRSADIA LVAGGSRKRW IIATENMQAG DTILNSNHIG RMAVAAREGD AHPLGALPVG TLINNVESEP GR |
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and aid in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) comprised of a small 28S subunit and a large 39S subunit. Among different species, the proteins comprising the mitoribosome vary greatly in sequence, and sometimes in biochemical properties, thus preventing simple recognition by sequence homology. Mitochondrial Ribosomal Protein L2 (MRPL2) is a 39S subunit protein which is a member of the EcoL2 ribosomal protein family.
MRPL2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 142 amino acids (84-202 a.a) and having a molecular mass of 15.5kDa.MRPL2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | MRPL2: a mitochondrial ribosomal protein encoded by a nuclear gene that helps in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL2 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 12q. [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Protein type:Ribosomal; Mitochondrial; RNA-binding; Motility/polarity/chemotaxis; Translation Chromosomal Location of Human Ortholog: 6p21.3 Cellular Component: mitochondrial inner membrane; mitochondrial large ribosomal subunit Molecular Function:structural constituent of ribosome Biological Process: mitochondrial translation |
| NCBI Summary: | Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL2 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 12q. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014] |
| UniProt Code: | Q5T653 |
| NCBI GenInfo Identifier: | 118573672 |
| NCBI Gene ID: | 51069 |
| NCBI Accession: | Q5T653.2 |
| UniProt Secondary Accession: | Q5T653,Q8WUL1, Q96Q56, Q9Y311, B2RC56, |
| UniProt Related Accession: | Q5T653 |
| Molecular Weight: | 33,301 Da |
| NCBI Full Name: | 39S ribosomal protein L2, mitochondrial |
| NCBI Synonym Full Names: | mitochondrial ribosomal protein L2 |
| NCBI Official Symbol: | MRPL2�� |
| NCBI Official Synonym Symbols: | CGI-22; RPML14; MRP-L14�� |
| NCBI Protein Information: | 39S ribosomal protein L2, mitochondrial |
| UniProt Protein Name: | 39S ribosomal protein L2, mitochondrial |
| Protein Family: | 39S ribosomal protein |
| UniProt Gene Name: | MRPL2�� |
| UniProt Entry Name: | RM02_HUMAN |
Additional Information
Product Type: |
Recombinant Protein |
Species: |
Human |
Uniprot: |
Q5T653 |
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