Human MRPL13 Recombinant Protein (RPPB4004)
- SKU:
- RPPB4004
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9BYD1
Description
| Product Name: | Human MRPL13 Recombinant Protein |
| Product Code: | RPPB4004 |
| Size: | 20µg |
| Species: | Human |
| Target: | MRPL13 |
| Synonyms: | L13, L13A, L13mt, RPL13, RPML13, 39S ribosomal protein L13, mitochondrial, MRPL13. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | MRPL13 protein solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMSSFSRA PQQWATFARI WYLLDGKMQP PGKLAAMASI RLQGLHKPVY HALSDCGDHV VIMNTRHIAF SGNKWEQKVY SSHTGYPGGF RQVTAAQLHL RDPVAIVKLA IYGMLPKNLH RRTMMERLHL FPDEYIPEDI LKNLVEELPQ PRKIPKRLDE YTQEEIDAFP RLWTPPEDYR L |
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and assist in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit (MRPL13 is a 39S subunit protein) and have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. An additional difference between mammalian mitoribosomes and prokaryotic ribosomes is that the second contain a 5S rRNA. Among various species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology.
MRPL13 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 201 amino acids (1-178 a.a.) and having a molecular mass of 23.1kDa. MRPL13 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | MRPL13: a mitochondrial ribosomal protein encoded by a nuclear gene that helps in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Protein type:Translation; RNA-binding; Mitochondrial; Ribosomal Chromosomal Location of Human Ortholog: 8q22.1-q22.3 Cellular Component: mitochondrial inner membrane; mitochondrial ribosome; mitochondrial large ribosomal subunit Molecular Function:protein binding; structural constituent of ribosome Biological Process: translation; mitochondrial translation; organelle organization and biogenesis |
| NCBI Summary: | Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9BYD1 |
| NCBI GenInfo Identifier: | 22257023 |
| NCBI Gene ID: | 28998 |
| NCBI Accession: | Q9BYD1.1 |
| UniProt Secondary Accession: | Q9BYD1,Q9UI04, B2R4R8, |
| UniProt Related Accession: | Q9BYD1 |
| Molecular Weight: | 178 |
| NCBI Full Name: | 39S ribosomal protein L13, mitochondrial |
| NCBI Synonym Full Names: | mitochondrial ribosomal protein L13 |
| NCBI Official Symbol: | MRPL13�� |
| NCBI Official Synonym Symbols: | L13; L13A; L13mt; RPL13; RPML13�� |
| NCBI Protein Information: | 39S ribosomal protein L13, mitochondrial; MRP-L13 |
| UniProt Protein Name: | 39S ribosomal protein L13, mitochondrial |
| Protein Family: | 39S ribosomal protein |
| UniProt Gene Name: | MRPL13�� |
| UniProt Entry Name: | RM13_HUMAN |
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