Human MRPL1 Recombinant Protein (RPPB4001)
- SKU:
- RPPB4001
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9BYD6
Description
| Product Name: | Human MRPL1 Recombinant Protein |
| Product Code: | RPPB4001 |
| Size: | 20µg |
| Species: | Human |
| Target: | MRPL1 |
| Synonyms: | BM022, L1MT, MRP-L1, 39S ribosomal protein L1, mitochondria, MRPL1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The MRPL1 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 30% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 80% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSKKTKKGA KEKTPDEKKD EIEKIKAYPY MEGEPEDDVY LKRLYPRQIY EVEKAVHLLK KFQILDFTSP KQSVYLDLTL DMALGKKKNV EPFTSVLSLP YPFASEINKV AVFTENASEV KIAEENGAAF AGGTSLIQKI WDDEIVADFY VAVPEIMPEL NRLRKKLNKK YPKLSRNSIG RDIPKMLELF KNGHEIKVDE ERENFLQTKI ATLDMSSDQI AANLQAVINE VCRHRPLNLG PFVVRAFLRS STSEGLLLKI DPLLPKEVKN EESEKEDA |
Mitochondrial Ribosomal Protein L1 (MRPL1) exists as a component of the 39S ribosomal subunit and operates in conjunction with other MRPs to mediate protein synthesis. Mitochondrial ribosomes consist of a large 39S subunit and a small 28S subunit, both of which are consist of multiple mitochondrial ribosomal proteins (MRPs) that are encoded by nuclear genes and are vital for protein synthesis within mitochondria. MRPL1 exists as 2 isoforms produced by alternative splicing. Isoform 1 of MRPL1 is ubiquitously expressed while isoform 2 is particularly expressed in heart.
MRPL1 Human Recombinant produced in E. coli is a single polypeptide chain containing 298 amino acids (51-325) and having a molecular mass of 33.8kDa. MRPL1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | MRPL1: a mitochondrial ribosomal protein encoded by a nuclear gene that helps in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L1 ribosomal protein family. [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Protein type:RNA-binding; Mitochondrial Chromosomal Location of Human Ortholog: 4q21.1 Cellular Component: nucleoplasm; mitochondrion; mitochondrial inner membrane; large ribosomal subunit Molecular Function:structural constituent of ribosome Biological Process: mitochondrial translation; organelle organization and biogenesis |
| NCBI Summary: | Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L1 ribosomal protein family. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9BYD6 |
| NCBI GenInfo Identifier: | 239938694 |
| NCBI Gene ID: | 65008 |
| NCBI Accession: | Q9BYD6.2 |
| UniProt Secondary Accession: | Q9BYD6,Q4W5B8, Q6IAG4, Q96BW3, Q9H793, Q9NRL5, A6NG03 |
| UniProt Related Accession: | Q9BYD6 |
| Molecular Weight: | 325 |
| NCBI Full Name: | 39S ribosomal protein L1, mitochondrial |
| NCBI Synonym Full Names: | mitochondrial ribosomal protein L1 |
| NCBI Official Symbol: | MRPL1�� |
| NCBI Official Synonym Symbols: | L1MT; BM022; MRP-L1�� |
| NCBI Protein Information: | 39S ribosomal protein L1, mitochondrial |
| UniProt Protein Name: | 39S ribosomal protein L1, mitochondrial |
| Protein Family: | 39S ribosomal protein |
| UniProt Gene Name: | MRPL1�� |
| UniProt Entry Name: | RM01_HUMAN |
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