Human MRGPRX2 Full-Length Bioactive Membrane Protein (HDFP086)

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SKU:
HDFP086
Product Type:
Recombinant Protein
Protein Type:
Full-Length Bioactive Membrane Protein
Species:
Human
Uniprot:
Q96LB1

Description

system_update_altDatasheet
Product nameHuman MRGPRX2 full length protein-synthetic nanodisc
Size:10ug
Product SKU:HDFP086
Product CategoryFull Length Transmembrane Proteins
Target:MRGPRX2
Uniprot:Q96LB1
Description:Human MRGPRX2 full length protein-synthetic nanodisc
Molecular Weight:The human full length MRGPRX2 protein has a MW of 37.1 kDa
Protein Family:Druggable Genome, GPCR, Transmembrane
Protein Pathways:
Storage & Shipping:Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Synonyms:MGRG3; MRGX2
Expression System:HEK293
Formulation:Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.
Background:Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core (PubMed:25517090). Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction (By similarity). Acts as a receptor for a number of other ligands, including peptides and alkaloids, such as cortistatin-14, proadrenomedullin N-terminal peptides PAMP-12 and, at lower extent, PAMP-20, antibacterial protein LL-37, PMX-53 peptide, beta-defensins, and complanadine A.[UniProtKB/Swiss-Prot Function]
Delivery:3-4 weeks
UsageResearch use only
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