Enzymes Recombinant Proteins
Human MPO Recombinant Protein (RPPB2075)
- SKU:
- RPPB2075
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P05164
- Research Area:
- Enzymes
Description
| Product Name: | Human MPO Recombinant Protein |
| Product Code: | RPPB2075 |
| Size: | 25µg |
| Species: | Human |
| Target: | MPO |
| Synonyms: | Myeloperoxidase, EC 1.11.1.7, MPO. |
| Source: | Human peripheral blood polymorphonuclear leukocytes |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | MPO solution is supplied in 20mM HEPES buffer pH-7.5, 200mM NaCl and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 80% as determined by SDS-PAGE. |
Myeloperoxidase is an important enzyme used by granulocytes during phagocytic lysis of foreign particles engulfed. In normal tissues and in a variety of myeloproliferative disorders myeloid cells of both neutrophilic and eosinophilic types, at all stages of maturation, exhibit strong cytoplasmic reactivity for MPO. Erythroid precursors, megakaryocytes, lymphoid cells, mast cells, and plasma cells are nonreactive. MPO is not observed in the neoplastic cells of a wide variety of epithelial tumors and sarcomas. MPO is useful in differentiating between myeloid and lymphoid leukemias.
MPO is a natural protein having a molecular mass of 150kDa containing 2 subunits each of a heavy chain with 64kDa and a light chain with 13kDa. MPO is isolated from human peripheral blood polymorphonuclear leukocytes.
| UniProt Protein Function: | MPO: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Homodimer; disulfide-linked. Each monomer consists of a light and a heavy chain. Belongs to the peroxidase family. XPO subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 1.11.2.2; Oxidoreductase Chromosomal Location of Human Ortholog: 17q23.1 Cellular Component: extracellular space; azurophil granule; mitochondrion; lysosome; nucleus; secretory granule Molecular Function:heparin binding; peroxidase activity; metal ion binding; heme binding; chromatin binding Biological Process: respiratory burst during defense response; response to food; removal of superoxide radicals; response to mechanical stimulus; hydrogen peroxide catabolic process; defense response; response to yeast; response to lipopolysaccharide; response to oxidative stress; defense response to fungus; negative regulation of apoptosis; aging Disease: Myeloperoxidase Deficiency; Alzheimer Disease |
| NCBI Summary: | Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P05164 |
| NCBI GenInfo Identifier: | 129825 |
| NCBI Gene ID: | 4353 |
| NCBI Accession: | P05164.1 |
| UniProt Secondary Accession: | P05164,Q14862, Q4PJH5, Q9UCL7, A1L4B8, |
| UniProt Related Accession: | P05164 |
| Molecular Weight: | 87,248 Da |
| NCBI Full Name: | Myeloperoxidase |
| NCBI Synonym Full Names: | myeloperoxidase |
| NCBI Official Symbol: | MPO�� |
| NCBI Protein Information: | myeloperoxidase |
| UniProt Protein Name: | Myeloperoxidase |
| Protein Family: | Myeloperoxidase |
| UniProt Gene Name: | MPO�� |
| UniProt Entry Name: | PERM_HUMAN |
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