Human/Mouse/Rat CD47 Antibody (Biotin) [MIAP410](AGEL0108)

Human/Mouse/Rat CD47 Monoclonal Antibody (Biotin Conjugated) [MIAP410](AGEL0108)

SKU AGEL0108

Product Type Antibody

Antibody Type Monoclonal Antibody

Host Species Mouse

Isotype IgG1

Clone MIAP410

Conjugation Biotin

Applications FC

Description

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Antibody Name:	Human/Mouse/Rat CD47 Monoclonal Antibody (Biotin Conjugated)
Antibody Code:	AGEL0108
Size:	100µg
Clone:	MIAP410
Synonyms:	Leukocyte surface antigen CD47, Cd47, Integrin-associated protein, IAP
Host Species:	Mouse
Species Reactivity:	Human, Mouse, Rat
Applications:	FC

Concentration:	1mg/mL
Isotype:	IgG1
Conjugation:	Biotin
Applications:	FC
Recommended Dilution:	Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 10e6 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Storage Buffer:	PBS with 0.05% Proclin300, 1% BSA
Storage:	Keep as concentrated solution.Store at 2-8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.

Gene ID:	9611642329364
Uniprot:	Q08722, Q61735, P97829
Background:	CD47, also known as Integrin-Associated Protein (IAP), is a membrane protein of about 50 kD with an IgV-like extracelluluar domain, a five membrane-spanning segment and a short terminal cytoplasmic region. It is widely expressed on many cell types and often associated with beta 3 integrins. It has been reported that CD47 functions as a self marker. Red cells lacking CD47 were rapidly cleared from the bloodstream by splenic macrophages. By binding to SIRPα, CD47 controls hemostatic innate immune functions, such as phagocytosis and cell trafficking.