Enzymes Recombinant Proteins

Human MMP 3 Recombinant Protein (RPPB1959)

(No reviews yet) Write a Review
SKU:
RPPB1959
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P08254
Research Area:
Enzymes

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human MMP 3 Recombinant Protein
Product Code:RPPB1959
Size:5µg
Species:Human
Target:MMP 3
Synonyms:Stromelysin-1, EC 3.4.24.17, Matrix metalloproteinase-3, MMP-3, Transin-1, SL-1, STMY, STR1, STMY1, MGC126102, MGC126103, MGC126104.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:MMP-3 is supplied in 50mM Tris-Acetate, pH-7.5, 1mM EDTA and 20% Glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.

MMP-3 enzyme is also known as Stromelysin-1or as Transin-1 which hydrolyzes natural collagen at physiological pH and temperature. It dissolves the intervertebral nucleus pulposus and annulus fibrosus of Herniated Lumbar Intervertebral Disk . MMP-3 hydrolyzes components of the extracellular matrix like proteoglycan, laminin, fibronectin, gelatin and collagen types III, IV and IX. It also activates pro-MMP-9 and pro-MMP-8 and superactivates plasmin activated MMP-1. MMP-3 is secreted as a latent proenzyme and is activated by a variety of proteinases, e.g. plasmin, trypsin, chymotrypsin, cathepsin G or human neutrophil elastase. MMP-3 was found to be capable of activating the precursor of IL1-beta.

MMP-3 Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain fused to a GST tag containing 228 amino acids (251-478) and having a total molecular mass of 51kDa. MMP-3 is purified by proprietary chromatographic techniques.

UniProt Protein Function:MMP3: Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase. Defects in MMP3 are the cause of susceptibility to coronary heart disease type 6 (CHDS6). A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries. A polymorphism in the MMP3 promoter region is associated with the risk of coronary heart disease and myocardial infarction, due to lower MMP3 proteolytic activity and higher extracellular matrix deposition in atherosclerotic lesions. Belongs to the peptidase M10A family.
UniProt Protein Details:

Protein type:Secreted; EC 3.4.24.17; Motility/polarity/chemotaxis; Secreted, signal peptide; Protease

Chromosomal Location of Human Ortholog: 11q22.3

Cellular Component: proteinaceous extracellular matrix; extracellular space; mitochondrion; extracellular region; cytosol

Molecular Function:zinc ion binding; metalloendopeptidase activity; endopeptidase activity; calcium ion binding

Biological Process: extracellular matrix disassembly; positive regulation of protein oligomerization; collagen catabolic process; extracellular matrix organization and biogenesis; negative regulation of protein kinase B signaling cascade; protein catabolic process; proteolysis; regulation of cell migration

Disease: Coronary Heart Disease, Susceptibility To, 6

NCBI Summary:Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
UniProt Code:P08254
NCBI GenInfo Identifier:116857
NCBI Gene ID:4314
NCBI Accession:P08254.2
UniProt Secondary Accession:P08254,Q3B7S0, Q6GRF8, B2R8B8,
UniProt Related Accession:P08254
Molecular Weight:53,977 Da
NCBI Full Name:Stromelysin-1
NCBI Synonym Full Names:matrix metallopeptidase 3 (stromelysin 1, progelatinase)
NCBI Official Symbol:MMP3��
NCBI Official Synonym Symbols:SL-1; STMY; STR1; CHDS6; MMP-3; STMY1��
NCBI Protein Information:stromelysin-1; transin-1; proteoglycanase; matrix metalloproteinase-3; matrix metalloproteinase 3 (stromelysin 1, progelatinase)
UniProt Protein Name:Stromelysin-1
UniProt Synonym Protein Names:Matrix metalloproteinase-3; MMP-3; Transin-1
Protein Family:Stromelysin
UniProt Gene Name:MMP3��
UniProt Entry Name:MMP3_HUMAN
View AllClose

0 Reviews

View AllClose

Related Products

Human MMP-3 Recombinant Protein (RPES0996)

Human MMP-3 Recombinant Protein (RPES0996)

Proteases Recombinant Proteins

system_update_altDatasheetHuman MMP-3 Recombinant Protein MMP3 is a member of the matrix metalloproteinase (MMP) family whose members are involved in the breakdown of extracellular matrix in norm
Human MMP-2 Recombinant Protein (RPES4601)

Human MMP-2 Recombinant Protein (RPES4601)

system_update_altDatasheetHuman MMP-2 Recombinant Protein 72 kDa type IV collagenase also known as matrix metalloproteinase-2 (MMP-2) and gelatinase A is an enzyme that in humans is encoded by th