Human MMP-2 Recombinant Protein (RPES2264)

Human MMP-2 Recombinant Protein

Metalloproteinase-2 (MMP-2) is a metalloproteinase that degrades components of the extracellular matrix, which plays an important role in cell migration during physiological and pathological processes. MMP-2 expression is enhanced by extracellular matrix metalloproteinase inducer (EMMPRIN); Her2/neu; growth factors; cytokines; and hormones. Pro-MMP-2 activation needs MT1-MMP and TIMP-2 contribution. After unilateral cochlear ablation, MMP-2 is altered in distribution and amount in the ventral cochlear nucleus. Low levels of MMP-2 have a better prognosis in hormone receptor-negative tumors, which are typically associated with a higher risk. As a proteolytic activation-requiring zymogen with catalytic activity; MMP-2 has been linked to cancer invasion and metastasis in many cell culture systems, including human breast cancer (HBC). Blocking MMP-2 production and activation during breast cancer development might help prevent metastasis. Active MMP-2 alone or the rate of pro-MMP-2 and active MMP-2 are considered a very sensitive indicator of cancer metastasis. Modulation of MMP-2 expression and activation through specific inhibitors and activators may provide a new approach for breast cancer therapy. Human MMP-2 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.