Human MLLT11 Recombinant Protein (RPPB3980)

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SKU:
RPPB3980
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q13015

Description

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Product Name:Human MLLT11 Recombinant Protein
Product Code:RPPB3980
Size:20µg
Species:Human
Target:MLLT11
Synonyms:AF1Q, RP11-316M1.10, Protein AF1q, MLLT11.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:MLLT11 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 80.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMRDPVSS QYSSFLFWRM PIPELDLSEL EGLGLSDTAT YKVKDSSVGK MIGQATAADQ EKNPEGDGLL EYSTFNFWRA PIASIHSFEL DLL

Myeloid/Lymphoid Leukemia Translocated To 11 (MLLT11) is a part of the Mixed-Lineage Leukemia protein family. MLLT11 which takes part in leukemogenesis and in the progression of severe monocytic leukemia (AML) is located on chromosome 11q23. MLLT11 which is also expressed in embryonic brain cortex is upregulated during neuronal differentiation and is taking part in the evolution of the central nervous system.

MLLT11 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 113 amino acids (1-90 a.a) and having a molecular mass of 12.4kDa. MLLT11 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:
UniProt Protein Details:
NCBI Summary:The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested. [provided by RefSeq, Jul 2008]
UniProt Code:Q13015
NCBI GenInfo Identifier:16307091
NCBI Gene ID:10962
NCBI Accession:BC009624
UniProt Secondary Accession:Q13015
UniProt Related Accession:Q13015
Molecular Weight:
NCBI Full Name:Homo sapiens myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11, mRNA
NCBI Synonym Full Names:MLLT11 transcription factor 7 cofactor
NCBI Official Symbol:MLLT11��
NCBI Official Synonym Symbols:AF1Q��
NCBI Protein Information:protein AF1q
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