Human MLANA Recombinant Protein (RPPB3977)

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SKU:
RPPB3977
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q16655

Description

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Product Name:Human MLANA Recombinant Protein
Product Code:RPPB3977
Size:20µg
Species:Human
Target:MLANA
Synonyms:MART-1, MART1, Melanoma antigen recognized by T-cells 1, Antigen LB39-AA, Antigen SK29-AA, Protein Melan-A, MLANA.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The MLANA solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSCRRRNGY RALMDKSLHV GTQCALTRRC PQEGFDHRDS KVSLQEKNCE PVVPNAPPAY EKLSAEQSPP PYSP

Melan-A (MLANA), is engaged in melanosome biogenesis by ensuring the stability of GPR143. MLANA takes part in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is essential to the formation of stage II melanosomes.

MLANA Human Recombinant produced in E. coli is a single polypeptide chain containing 94 amino acids (48-118) and having a molecular mass of 10.4kDa. MLANA is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:MLANA: Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.
UniProt Protein Details:

Protein type:Membrane protein, integral; Cell surface

Chromosomal Location of Human Ortholog: 9p24.1

Cellular Component: endoplasmic reticulum membrane; Golgi apparatus; integral to plasma membrane; melanosome; trans-Golgi network

Molecular Function:protein binding

UniProt Code:Q16655
NCBI GenInfo Identifier:2833278
NCBI Gene ID:2315
NCBI Accession:Q16655.1
UniProt Secondary Accession:Q16655,Q6ICU4,
UniProt Related Accession:Q16655
Molecular Weight:13,157 Da
NCBI Full Name:Melanoma antigen recognized by T-cells 1
NCBI Synonym Full Names:melan-A
NCBI Official Symbol:MLANA��
NCBI Official Synonym Symbols:MART1; MART-1��
NCBI Protein Information:melanoma antigen recognized by T-cells 1
UniProt Protein Name:Melanoma antigen recognized by T-cells 1
UniProt Synonym Protein Names:Antigen LB39-AA; Antigen SK29-AA; Protein Melan-A
Protein Family:Melanoma antigen recognized by T-cells
UniProt Gene Name:MLANA��
UniProt Entry Name:MAR1_HUMAN
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