Cell Death Recombinant Proteins
Human MKK6 Recombinant Protein (RPES1910)
- SKU:
- RPES1910
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Cell Death
Description
Human MKK6 Recombinant Protein
Dual specificity mitogen-activated protein kinase kinase 6; also known as MAP kinase kinase 6; MAPKK 6; MAPK / ERK kinase 6; SAPKK3; MAP2K6 and MKK6; is a protein which belongs to the?protein kinase superfamily; STE Ser / Thr protein kinase family and MAP kinase kinase subfamily. MAP2K6 / MKK6 contains one?protein kinase domain. Mitogen-activated protein kinases are members of a conserved cascade of kinases involved in many signal transduction pathways. They stimulate phosphorylation of transcription factors in response to extracellular signals such as growth factors; cytokines; ultraviolet light; and stress-inducing agents. MAP2K6 / MKK6 exists in a variety of alternatively spliced isoforms with distinct patterns of tissue expression. Isoform 2 of MAP2K6 / MKK6 is only expressed in skeletal muscle. Isoform 1 of MAP2K6 / MKK6 is expressed in skeletal muscle; heart; and in lesser extent in liver or pancreas.
| Product Name: | Human MKK6 Recombinant Protein (RPES1910) |
| Product Code: | RPES1910 |
| Size: | 20µg |
| Species: | Human |
| Expressed Host: | Baculovirus-Insect Cells |
| Synonyms: | MAPKK6,MEK6,MKK6,PRKMK6,SAPKK-3,SAPKK3,MAP2K6 |
| Accession: | P52564-1 |
| Sequence: | Met 1-Asp 334; Ser 207/Asp; Thr 211/Asp |
| Fusion tag: | N-His & GST |
| Activity: | The specific activity was determined to be 1250 nmol/min/mg using inactive MAPK14 as substrate. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the human MAP2K6 isoform 1 (P52564-1) (Met 1-Asp 334; Ser 207/Asp; Thr 211/Asp) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus. |
| Purity: | > 88 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 65.3 kDa |
| AP Mol Mass: | 60 kDa |
| Formulation: | Supplied as sterile 20mM Tris; 500mM NaCl; pH 8.0; 10% glycerol |
| Shipping: | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C. |
| Stability and Storage: | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
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