Chemokines Recombinant Proteins
Human MIG Recombinant Protein (RPPB1209)
- SKU:
- RPPB1209
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q07325
- Research Area:
- Chemokines
Description
| Product Name: | Human MIG Recombinant Protein |
| Product Code: | RPPB1209 |
| Size: | 20µg |
| Species: | Human |
| Target: | MIG |
| Synonyms: | C-X-C motif chemokine 9, CMK, crg-10, Humig, MIG, SCYB9, Gamma-interferon-induced monokine, Monokine induced by interferon-gamma, HuMIG, Small-inducible cytokine B9, CXCL9. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | MIG protein solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl and 30% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSTPVVRKG RCSCISTNQG TIHLQSLKDL KQFAPSPSCE KIEIIATLKN GVQTCLNPDS ADVKELIKKW EKQVSQKKKQ KNGKKHQKKK VLKVRKSQRS RQKKTT |
MIG (CXCL9) is a small cytokine which is part of the CXC chemokine family. MIG, which is also recognized as monokine is induced by gamma interferon. MIG is related to 2 other CXC chemokines named CXCL10 and CXCL11, whose genes are located next to the gene for CXCL9 on human chromosome 4. CXCL9, CXCL10 and CXCL11 obtain their chemotactic functions by interacting with the chemokine receptor CXCR3.
MIG Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 126 amino acids (23-125 a.a.) and having a molecular mass of 14kDa.MIG is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | CXCL9: Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3. Belongs to the intercrine alpha (chemokine CxC) family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 4q21 Cellular Component: extracellular space; extracellular region; external side of plasma membrane Molecular Function:protein binding; CXCR3 chemokine receptor binding; chemokine activity; cytokine activity Biological Process: positive regulation of leukocyte chemotaxis; response to lipopolysaccharide; defense response; positive regulation of cAMP metabolic process; signal transduction; chemotaxis; positive regulation of myoblast differentiation; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; cell-cell signaling; cellular defense response; immune response; positive regulation of release of sequestered calcium ion into cytosol; inflammatory response; defense response to virus |
| NCBI Summary: | This antimicrobial gene encodes a protein thought to be involved in T cell trafficking. The encoded protein binds to C-X-C motif chemokine 3 and is a chemoattractant for lymphocytes but not for neutrophils. [provided by RefSeq, Sep 2014] |
| UniProt Code: | Q07325 |
| NCBI GenInfo Identifier: | 585487 |
| NCBI Gene ID: | 4283 |
| NCBI Accession: | Q07325.1 |
| UniProt Secondary Accession: | Q07325,Q503B4, |
| UniProt Related Accession: | Q07325 |
| Molecular Weight: | Approximately 150 kDa |
| NCBI Full Name: | C-X-C motif chemokine 9 |
| NCBI Synonym Full Names: | chemokine (C-X-C motif) ligand 9 |
| NCBI Official Symbol: | CXCL9�� |
| NCBI Official Synonym Symbols: | CMK; MIG; Humig; SCYB9; crg-10�� |
| NCBI Protein Information: | C-X-C motif chemokine 9; small-inducible cytokine B9; gamma-interferon-induced monokine; monokine induced by gamma interferon; monokine induced by interferon-gamma |
| UniProt Protein Name: | C-X-C motif chemokine 9 |
| UniProt Synonym Protein Names: | Gamma-interferon-induced monokine; Monokine induced by interferon-gamma; HuMIG; MIG; Small-inducible cytokine B9 |
| Protein Family: | Migration and invasion enhancer |
| UniProt Gene Name: | CXCL9�� |
| UniProt Entry Name: | CXCL9_HUMAN |
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