Growth Factors & Cytokines Recombinant Proteins
Human MIF Recombinant Protein (RPES4040)
- SKU:
- RPES4040
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Growth Factors & Cytokines
Description
Human MIF Recombinant Protein
The human MIF protein is a 12.5 kDa, 115 amino acid (aa) nonglycosylated polypeptide generated without a signal sequence. Secretion occurs nonclassically via an ABCA1 transporter. MIF is a pro-inflammatory cytokine that plays a role in the innate immune response to bacterial infections. MIF's presence at inflammatory sites appears to suggest it has a role in host defense by mediating the activity of acrophages. MIF counteracts the anti-inflammatory activity of glucocorticoids. However, MIF has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), although the physiological substrate is unknown. It's not clear whether the tautomerase activity has any physiological significance or if it is required for cytokine action. Human MIF Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
| Product Name: | Human MIF Recombinant Protein (RPES4040) |
| Product Code: | RPES4040 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | E.coli |
| Synonyms: | Macrophage migration inhibitory factor, MIF, MMIF, Glycosylation-inhibiting factor, GLIF, L-dopachrome tautomerase, Phenylpyruvate tautomerase |
| Accession: | P14174 |
| Sequence: | Met 1-Ala115 |
| Fusion tag: | |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Macrophage migration inhibitory factor is produced by our E.coli expression system and the target gene encoding Met1-Ala115 is expressed. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 12.5 kDa |
| AP Mol Mass: | 10-14 kDa |
| Formulation: | Supplied as a 0.2 µm filtered solution of 20mM PB,150mM NaCl,20% Glycerol,pH7.4. |
| Shipping: | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C. |
| Stability and Storage: | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
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