Human MICB Recombinant Protein (RPES3102)
- SKU:
- RPES3102
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
Human MICB Recombinant Protein
MHC class I polypeptide-related sequence B; also known as MICB; is a heavily glycosylated protein serving as a ligand for the type I I receptor NKG2D. MICB shares 85% amino acid identity with MICA; a closely related protein; both of which contain three extracellular immunoglobulin-like domains; but without capacity to bind peptide or interact with beta-2-microglobulin. acting as a stress-induced self-antigen; binding of MICB to the NKG2D receptor activates the cytolytic response of natural killer (NK) cells; CD8+?β T cells; and ?? T cells on which the receptor is expressed. MICA/B are minimally expressed on normal cells; but are frequently expressed on epithelial tumors and can be induced by bacterial and viral infections. MICA/B recognition thus is involved in tumor surveillance; viral infections; and autoimmune diseases.
| Product Name: | Human MICB Recombinant Protein (RPES3102) |
| Product Code: | RPES3102 |
| Size: | 50µg |
| Species: | Human |
| Expressed Host: | HEK293 Cells |
| Synonyms: | PERB11.2 |
| Accession: | NP_005922.2 |
| Sequence: | Met 1-Gly 298 |
| Fusion tag: | C-His & Fc |
| Activity: | Immobilized human His-NKG2D (78-216) at 10 µg/ml (100 ?l/well) can bind human MICB-Fch; The EC50 of human MICB-Fch is 15.9-37.1 ng/ml. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the extracellular domain of human MICB (NP_005922.2) (Met 1-Gly 298) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus. |
| Purity: | > 98 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 59.5 kDa |
| AP Mol Mass: | 80-90 kDa |
| Formulation: | Lyophilized from sterile PBS; pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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