Human MGP Recombinant Protein (RPPB3970)

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RPPB3970

Description

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Product Name:Human MGP Recombinant Protein
Product Code:RPPB3970
Size:20µg
Species:Human
Target:MGP
Synonyms:Matrix Gla protein, Cell growth-inhibiting gene 36 protein, MGLAP, NTI.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The MGP solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MYESHESMES YELNPFINRR NANTFISPQQ RWRAKVQERI RERSKPVHEL NREACDDYRL CERYAMVYGY NAAYNRYF

MGP is vital for the regulation of calcification in the extracellular matrix, particularly in cartilage and arteries. The K-dependent vitamin MGP has five to six residues of Gla, a Ca2+ binding amino acid crucial for vitamin K-dependent gamma carboxylase for its formation. MGP is formed by COOH-terminal processing by carboxypeptidase B-like enzymatic activity and localized in the human bone.

MGP Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 98 amino acids (20-96) and having a molecular mass of 11.8 kDa.The MGP is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:MGP: Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation. Defects in MGP are the cause of Keutel syndrome (KS). KS is an autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia. Belongs to the osteocalcin/matrix Gla protein family.
UniProt Protein Details:

Protein type:Secreted; Extracellular matrix; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12p12.3

Cellular Component: extracellular matrix; proteinaceous extracellular matrix

Molecular Function:protein binding; structural constituent of bone; extracellular matrix structural constituent; calcium ion binding

Biological Process: ossification; cell differentiation; regulation of bone mineralization; cartilage condensation

Disease: Keutel Syndrome

NCBI Summary:The protein encoded by this gene is secreted and likely acts as an inhibitor of bone formation. The encoded protein is found in the organic matrix of bone and cartilage. Defects in this gene are a cause of Keutel syndrome (KS). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
UniProt Code:P08493
NCBI GenInfo Identifier:118572668
NCBI Gene ID:4256
NCBI Accession:P08493.2
UniProt Secondary Accession:P08493,Q2TU41, Q567P9, Q6ICN5, A0M8W5, B2R519, J3KMX7
UniProt Related Accession:P08493
Molecular Weight:103
NCBI Full Name:Matrix Gla protein
NCBI Synonym Full Names:matrix Gla protein
NCBI Official Symbol:MGP��
NCBI Official Synonym Symbols:NTI; GIG36; MGLAP��
NCBI Protein Information:matrix Gla protein; cell growth-inhibiting gene 36 protein
UniProt Protein Name:Matrix Gla protein
UniProt Synonym Protein Names:Cell growth-inhibiting gene 36 protein
Protein Family:Matrix Gla protein
UniProt Gene Name:MGP��
UniProt Entry Name:MGP_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P08493
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