Enzymes Recombinant Proteins
Human METTL1 Recombinant Protein (RPPB1939)
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- SKU:
- RPPB1939
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9UBP6
- Research Area:
- Enzymes
Description
| Product Name: | Human METTL1 Recombinant Protein |
| Product Code: | RPPB1939 |
| Size: | 10µg |
| Species: | Human |
| Target: | METTL1 |
| Synonyms: | Methyltransferase-Like 1, TRM8, tRNA(m7G46)-methyltransferase, tRNA (guanine-N(7)-)-methyltransferase , C12orf1, YDL201w, D1075-like gene product, FLJ95748, EC 2.1.1.33. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The METTL1 protein solution (0.5mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0)1mM DTT, 50mM NaCl and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MAAETRNVAG AEAPPPQKRY YRQRAHSNPM ADHTLRYPVK PEEMDWSELY PEFFAPLTQN QSHDDPKDKK EKRAQAQVEF ADIGCGYGGL LVELSPLFPD TLILGLEIRV KVSDYVQDRI RALRAAPAGG FQNIACLRSN AMKHLPNFFY KGQLTKMFFL FPDPHFKRTK HKWRIISPTL LAEYAYVLRV GGLVYTITDV LELHDWMCTH FEEHPLFERV PLEDLSEDPV VGHLGTSTEE GKKVLRNGGK NFPAIFRRIQ DPVLQAVTSQ TSLPGH |
METTL1 is recognized as tRNA (guanine-N(7)-)-methyltransferase that is a part of the methyltransferase superfamily. METTL1 displays high sequence similarity to yeast ORF YDL201w and can be inactivated by phosphorylation. METTL1 protein has a conserved S-adenosylmethionine-binding motif and ccatalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
Recombinant Human METTL1 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 296 amino acids (1-276a.a.) and having a molecular mass of 33.6kDa.METTL1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. |
| NCBI Summary: | This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding different protein isoforms have been described for this gene. A pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UBP6 |
| NCBI GenInfo Identifier: | 32171926 |
| NCBI Gene ID: | 4234 |
| NCBI Accession: | Q9UBP6.1 |
| UniProt Secondary Accession: | Q9UBP6,Q14105, Q53FS9, B2RBX1, H7BXF2, |
| UniProt Related Accession: | Q9UBP6 |
| Molecular Weight: | 17,423 Da |
| NCBI Full Name: | tRNA (guanine-N(7)-)-methyltransferase |
| NCBI Synonym Full Names: | methyltransferase like 1 |
| NCBI Official Symbol: | METTL1�� |
| NCBI Official Synonym Symbols: | TRM8; TRMT8; C12orf1; YDL201w�� |
| NCBI Protein Information: | tRNA (guanine-N(7)-)-methyltransferase |
| UniProt Protein Name: | tRNA (guanine-N(7)-)-methyltransferase |
| UniProt Synonym Protein Names: | Methyltransferase-like protein 1 |
| UniProt Gene Name: | METTL1�� |
| UniProt Entry Name: | TRMB_HUMAN |
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