Human METAP1 Recombinant Protein (RPES5025)

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SKU:
RPES5025
Product Type:
Recombinant Protein
Species:
Human

Description

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Human METAP1 Recombinant Protein

Processing of the N-terminal initiator methionine or formylated methionine is an essential cellular process conserved from prokaryotes to eukaryotes. The proteolytic removal of N-terminal methionine from nascent peptides is catalyzed by a family of enzymes known as methionine aminopeptidases (MetAPs) and is essential for cell growth. METAP1 and METAP2 have different substrate specificity due to the differences in both size and shape of the active sites. As a member of the M24 family of metalloproteases, METAP1 plays an important role in G(2)/M phase regulation of the cell cycle and may serve as a promising target for the discovery and development of new anticancer agents.

Product Name:Human METAP1 Recombinant Protein (RPES5025)
Product Code:RPES5025
Size:10µg
Species:Human
Expressed Host:HEK293 Cells
Synonyms:Methionine aminopeptidase 1, MAP 1, MetAP 1, Peptidase M 1, METAP1,MAP1A,MetAP1A
Accession:NP_055958.2
Sequence:Met 1-Phe 272
Fusion tag:N-Fc
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:A DNA sequence encoding the N-terminal domain (Met 1-Phe 272) of human METAP1 (NP_055958.2) was fused with the Fc region of human IgG1 at the N-terminus.
Purity:> 85 % as determined by reducing SDS-PAGE.
Mol Mass:57 kDa
AP Mol Mass:60-65 kDa
Formulation:Lyophilized from sterile PBS, pH 7.4
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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