Cell Biology Recombinant Proteins

Human Mesothelin/MSLN Recombinant Protein (RPES4510)

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RPES4510

Description

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Human Mesothelin/MSLN Recombinant Protein

Mesothelin is a cell surface glycoprotein whose expression is limited to mesothelial cells of the serosa (pleura; pericardium; and peritoneum) and epithelial cells of the trachea; tonsils; fallopian tube; and kidneys. Mesothelin plays an important role in cell survival; proliferation; migration; invasion; tumor progression; and resistance to chemotherapy. The overexpression of mesothelin can activate NF-?B and signal transducer and activator of transcription 3 (Stat3); inhibit apoptotic signaling and TNF-?-induced apoptosis; and accelerate the G1–S transition. Mesothelin is also found overexpressed in various cancers; including malignant mesothelioma; pancreatic or ovarian carcinoma; sarcomas and in some gastrointestinal or pulmonary carcinomas. As a result of its limited expression in normal tissues; mesothelin has been reported as an ideal tumor-associated marker for the development of targeted therapy.

Product Name:Human Mesothelin/MSLN Recombinant Protein (RPES4510)
Product Code:RPES4510
Size:10µg
Species:Human
Expressed Host:Human Cells
Synonyms:Megakaryocyte potentiating factor, mesothelin, Pre-pro-megakaryocyte-potentiating factor, soluble MPF mesothelin related protein,CAK1, MPF, MSLN, SMR, CAK1, CAK1 antigen
Accession:Q13421
Sequence:Leu37-Arg286
Fusion tag:C-Fc
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human Mesothelin is produced by our Mammalian expression system and the target gene encoding Leu37-Arg286 is expressed with a Fc tag at the C-terminus.
Purity:> 95 % as determined by reducing SDS-PAGE.
Mol Mass:53.9 kDa
AP Mol Mass:60-80 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of PBS; pH7.4.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Research Area:
Cell Biology
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