Human MESDC2 Recombinant Protein (RPPB3961)
- SKU:
- RPPB3961
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q14696
Description
| Product Name: | Human MESDC2 Recombinant Protein |
| Product Code: | RPPB3961 |
| Size: | 10µg |
| Species: | Human |
| Target: | MESDC2 |
| Synonyms: | LDLR chaperone MESD, Mesoderm development candidate 2, Mesoderm development protein, Renal carcinoma antigen NY-REN-61, MESDC2, KIAA0081, MESD, BOCA. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The MESDC2 solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1M NaCl and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MAEGSPGTPD ESTPPPRKKK KDIRDYNDAD MARLLEQWEK DDDIEEGDLP EHKRPSAPVD FSKIDPSKPE SILKMTKKGK TLMMFVTVSG SPTEKETEEI TSLWQGSLFN ANYDVQRFIV GSDRAIFMLR DGSYAWEIKD FLVGQDRCAD VTLEGQVYPG KGGGSKEKNK TKQDKGKKKK EGDLKSRSSK EENRAGNKRE DL |
Mesoderm development candidate 2 (MESDC2) is required for formation of the primitive streak and mesoderm during embryogenesis. MESDC2 binds to the Wnt co-receptors LRP5 and LRP6 in the endoplasmic reticulum and is required for their proper folding and cell surface expression.
MESDC2 Human Recombinant fused with a 21 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 222 amino acids (34-234 a.a.) and having a molecular mass of 24.9kDa (Molecular weight on SDS-PAGE will appear higher). The MESDC2 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | MESDC2: Chaperone specifically assisting the folding of beta- propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Monomer. Interacts with LRP5; the interaction prevents LRP5 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP6; the interaction prevents LRP6 from forming aggregates and chaperones LRP6 to the plasma membrane. Belongs to the MESD family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 15q13 Biological Process: protein folding |
| UniProt Code: | Q14696 |
| NCBI GenInfo Identifier: | 24418861 |
| NCBI Gene ID: | 23184 |
| NCBI Accession: | Q14696.2 |
| UniProt Secondary Accession: | Q14696,Q969U1, B4DW84, D3DW96, |
| UniProt Related Accession: | Q14696 |
| Molecular Weight: | 14,895 Da |
| NCBI Full Name: | LDLR chaperone MESD |
| NCBI Synonym Full Names: | mesoderm development candidate 2 |
| NCBI Official Symbol: | MESDC2�� |
| NCBI Official Synonym Symbols: | BOCA; MESD�� |
| NCBI Protein Information: | LDLR chaperone MESD |
| UniProt Protein Name: | LDLR chaperone MESD |
| UniProt Synonym Protein Names: | Mesoderm development candidate 2; Mesoderm development protein; Renal carcinoma antigen NY-REN-61 |
| Protein Family: | LDLR chaperone |
| UniProt Gene Name: | MESDC2�� |
| UniProt Entry Name: | MESD_HUMAN |
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