Human Meprin beta Subunit / MEP1B ELISA Kit

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SKU:
HUFI01546
Product Type:
ELISA Kit
Size:
96 Assays
Uniprot:
Q16820
Sensitivity:
0.938ng/ml
Range:
1.563-100ng/ml
ELISA Type:
Sandwich
Synonyms:
MEP1B, Meprin A subunit beta, Endopeptidase-2, PABA peptide hydrolase, PPH beta, Meprin beta Subunit, meprin A, beta, Meprin B, N-benzoyl-L-tyrosyl-p-amino-benzoic acid hydrolase beta subunit, N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subuni
Reactivity:
Human
Research Area:
Immunology

Description

Human Meprin beta Subunit / MEP1B ELISA

MEP1B (Meprin A Subunit Beta) is a protein-coding gene that when mutated in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in the kidney and intestine. Meprins are zinc metalloprotease enzymes that are highly expressed in mammalian kidney and intestinal brush border membranes, as well as leukocytes and certain cancer cells. Meprins are also involved in the breakdown of a range of peptide and protein substrates, as well as cancer and intestinal inflammation. Mature meprins are oligomers that have an alpha and beta subunit. Homooligomers of the alpha subunit is secreted however, oligomers containing the beta subunit are plasma membrane-bound. Powassan encephalitis and Colorado tick fever are examples of diseases linked to MEP1B. Activation of cAMP-Dependent PKA and signal transduction_PKA signalling are two of the many pathways that MEP1B are involved in. The gene ontology annotations for MEP1B include metalloendopeptidase activity and metallopeptidase activity. MEP1A is a paralog of MEP1B.

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