Human MEOX2 Recombinant Protein (RPPB3959)

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SKU:
RPPB3959
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P50222

Description

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Product Name:Human MEOX2 Recombinant Protein
Product Code:RPPB3959
Size:10µg
Species:Human
Target:MEOX2
Synonyms:GAX, MOX2, Homeobox protein MOX-2, Growth arrest-specific homeobox, Mesenchyme homeobox 2, MEOX2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The MEOX2 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 40% glycerol and 2mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSRKERTAF TKEQIRELEA EFAHHNYLTR LRRYEIAVNL DLTERQVKVW FQNRRMKWKR VKGGQQGAAA REKELVNVKK GTLLPSELSG IGAATLQQTG DSIANEDSHD SDHSSEHAHL

Homeobox protein MOX-2 (MEOX2) is a part of a family of nonclustered, diverged homeobox genes which are expressed in overlapping patterns in the paraxial mesoderm and its derivatives. MEOX2 participates in the regulation of vertebrate limb myogenesis. MEOX2 also takes part in mesoderm induction and its earliest regional specification, somitogenesis, myogenic and sclerotomal differentiation. Mutations in the related mouse MEOX2 are related with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease.

MEOX2 Human Recombinant produced in E. coli is a single polypeptide chain containing 140 amino acids (188-304) and having a molecular mass of 15.9kDa. MEOX2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:MEOX2: Role in mesoderm induction and its earliest regional specification, somitogenesis, and myogenic and sclerotomal differentiation. May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle.
UniProt Protein Details:

Protein type:DNA-binding

Chromosomal Location of Human Ortholog: 7p22.1-p21.3

Cellular Component: cytoplasm; nucleus

Molecular Function:protein binding; sequence-specific DNA binding; transcription factor activity

Biological Process: blood circulation; multicellular organismal development; positive regulation of transcription from RNA polymerase II promoter

NCBI Summary:This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease. [provided by RefSeq, Jul 2008]
UniProt Code:P50222
NCBI GenInfo Identifier:93141286
NCBI Gene ID:4223
NCBI Accession:P50222.2
UniProt Secondary Accession:P50222,O75263, Q9UPL6, B2R8I7,
UniProt Related Accession:P50222
Molecular Weight:33,594 Da
NCBI Full Name:Homeobox protein MOX-2
NCBI Synonym Full Names:mesenchyme homeobox 2
NCBI Official Symbol:MEOX2��
NCBI Official Synonym Symbols:GAX; MOX2��
NCBI Protein Information:homeobox protein MOX-2
UniProt Protein Name:Homeobox protein MOX-2
UniProt Synonym Protein Names:Growth arrest-specific homeobox; Mesenchyme homeobox 2
Protein Family:Homeobox protein
UniProt Gene Name:MEOX2��
UniProt Entry Name:MEOX2_HUMAN
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