Human MCAM Recombinant Protein (RPPB3943)

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SKU:
RPPB3943
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P43121

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human MCAM Recombinant Protein
Product Code:RPPB3943
Size:10µg
Species:Human
Target:MCAM
Synonyms:Cell surface glycoprotein MUC18,� Cell surface glycoprotein P1H12,� Melanoma cell adhesion molecule,� Melanoma-associated antigen A32,� Melanoma-associated antigen MUC18,� S-endo 1 endothelial-associated antigen,� CD146, MCAM, MUC18, Cell Surface Glycoprotein MUC18, Melanoma Adhesion Molecule, CD146 Antigen, CD146, Melanoma Cell Adhesion Molecule, S-Endo 1 Endothelial-Associated Antigen, Melanoma-Associated Antigen MUC18, Cell Surface Glycoprotein P1H12, Melanoma-Associated Antigen A32, Gicerin.
Source:Sf9 Insect cells
Physical Appearance:Sterile filtered colorless solution.
Formulation:MCAM protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:VPGEAEQPAP ELVEVEVGST ALLKCGLSQS QGNLSHVDWF SVHKEKRTLI FRVRQGQGQS EPGEYEQRLS LQDRGATLAL TQVTPQDERI FLCQGKRPRS QEYRIQLRVY KAPEEPNIQV NPLGIPVNSK EPEEVATCVG RNGYPIPQVI WYKNGRPLKE EKNRVHIQSS QTVESSGLYT LQSILKAQLV KEDKDAQFYC ELNYRLPSGN HMKESREVTV PVFYPTEKVW LEVEPVGMLK EGDRVEIRCL ADGNPPPHFS ISKQNPSTRE AEEETTNDNG VLVLEPARKE HSGRYECQGL DLDTMISLLS EPQELLVNYV SDVRVSPAAP ERQEGSSLTL TCEAESSQDL EFQWLREETG QVLERGPVLQ LHDLKREAGG GYRCVASVPS IPGLNRTQLV NVAIFGPPWM AFKERKVWVK ENMVLNLSCE ASGHPRPTIS WNVNGTASEQ DQDPQRVLST LNVLVTPELL ETGVECTASN DLGKNTSILF LELVNLTTLT PDSNTTTGLS TSTASPHTRA NSTSTERKLP EPESRGAAAL EHHHHHH

Cell surface glycoprotein MUC18 (MCAM), is an integral membrane glycoprotein which is part of the immunoglobulin superfamily. MCAM is related with a variety of carcinomas such as tumor progression, metastasis and is also implicated in embryonic neural development. In Addition, MCAM takes part in cell adhesion, as well as in cohesion of the endothelial monolayer at the intercellular junctions in vascular tissue.

MCAM produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 547 amino acids (24-559 a.a.) and having a molecular mass of 61.0kDa (Molecular size on SDS-PAGE will appear at approximately 70-100kDa).MCAM is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:MCAM: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: extracellular space; focal adhesion; integral to membrane; plasma membrane; nucleus; external side of plasma membrane

Biological Process: anatomical structure morphogenesis; glomerular filtration; angiogenesis; cell adhesion; positive regulation of cell migration

UniProt Code:P43121
NCBI GenInfo Identifier:85681878
NCBI Gene ID:4162
NCBI Accession:P43121.2
UniProt Secondary Accession:P43121,O95812, Q59E86, Q6PHR3, Q6ZTR2,
UniProt Related Accession:P43121
Molecular Weight:646
NCBI Full Name:Cell surface glycoprotein MUC18
NCBI Synonym Full Names:melanoma cell adhesion molecule
NCBI Official Symbol:MCAM��
NCBI Official Synonym Symbols:CD146; MUC18��
NCBI Protein Information:cell surface glycoprotein MUC18; Gicerin; melanoma adhesion molecule; cell surface glycoprotein P1H12; melanoma-associated antigen A32; melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen
UniProt Protein Name:Cell surface glycoprotein MUC18
UniProt Synonym Protein Names:Cell surface glycoprotein P1H12; Melanoma cell adhesion molecule; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen; CD_antigen: CD146
Protein Family:Cell surface glycoprotein
UniProt Gene Name:MCAM��
UniProt Entry Name:MUC18_HUMAN
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