Immunology Recombinant Proteins
Human MASP1 Recombinant Protein (RPES4231)
- SKU:
- RPES4231
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Immunology
Description
Human MASP1 Recombinant Protein
Mannan-Binding Lectin Serine Protease 1 (MASP-1) belongs to the peptidase S1 family. MASP1 contains two CUB domains, one EGF-like domain, one peptidase S1 domain and two Sushi (CCP/SCR) domains. MASP1 is primarily expressed in liver. MASP1 involved in the lectin pathway of the complement, performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. MASP1 is synthesized as a zymogen and activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. MASP1 is not directly involved in complement activation but may act as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP2. MASP1 is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. MASP1 is inhibited by SERPING1 and A2M.
| Product Name: | Human MASP1 Recombinant Protein (RPES4231) |
| Product Code: | RPES4231 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | Mannan-Binding Lectin Serine Protease 1, Complement Factor MASP-3,Mannose-Binding Lectin-Associated Serine Protease 1, MASP-1, RaRF, Serine Protease 5, MASP1, CRARF, CRARF1, PRSS5 |
| Accession: | P48740 |
| Sequence: | His20-Arg728 |
| Fusion tag: | C-6His |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Mannan-Binding Lectin Serine Protease 1 is produced by our Mammalian expression system and the target gene encoding His20-Arg728 is expressed with a 6His tag at the C-terminus. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 80.7 kDa |
| AP Mol Mass: | 120 kDa |
| Formulation: | Supplied as a 0.2 µm filtered solution of 20mM Tris,200mM NaCl,10µglycerol,pH8.0. |
| Shipping: | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C. |
| Stability and Storage: | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
Related Products
Human MASP1 Recombinant Protein (His tag)
Human TGFB1 Recombinant Recombinant Protein (RPPB0968)
Growth Factors & Cytokines Recombinant Proteins
Human Acrp30 Protein Recombinant Protein (RPPB5717)
Cytokines Recombinant Proteins
Human PIP Protein Recombinant Protein (RPPB0886)
Growth Factors & Cytokines Recombinant Proteins
Human Recombinant Protein S100P Recombinant Protein (His Tag) (RPES6517)
