Human MAPRE2 Recombinant Protein (RPPB3926)

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SKU:
RPPB3926
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q15555

Description

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Product Name:Human MAPRE2 Recombinant Protein
Product Code:RPPB3926
Size:20µg
Species:Human
Target:MAPRE2
Synonyms:Microtubule-associated protein RP/EB family member 2, APC-binding protein EB2, End-binding protein 2, EB2, MAPRE2, RP1, EB1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:MAPRE2 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 0.1M NaCl and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MPGPTQTLSP NGENNNDIIQ DNNGTIIPFR KHTVRGERSY SWGMAVNVYS TSITQETMSR HDIIAWVNDI VSLNYTKVEQ LCSGAAYCQF MDMLFPGCIS LKKVKFQAKL EHEYIHNFKL LQASFKRMNV DKVIPVEKLV KGRFQDNLDF IQWFKKFYDA NYDGKEYDPV EARQGQDAIP PPDPGEQIFN LPKKSHHANS PTAGAAKSSP AAKPGSTPSR PSSAKRASSS GSASKSDKDL ETQVIQLNEQ VHSLKLALEG VEKERDFYFG KLREIELLCQ EHGQENDDLV QRLMDILYAS EEHEGHTEEP EAEEQAHEQQ PPQQEEY

MAPRE2 (RP1 or EB2) is an evolutionarily conserved protein, which associates with the tips of growing microtubules, and regulates microtubule dynamics and their interactions with intracellular structures. The EB proteins regulate microtubule function through CLIP proteins. MAPRE2 shares noteworthy homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. MAPRE2 is necessary for spindle symmetry during mitosis. MAPRE2 is believed to have a role in the tumorigenesis of colorectal cancers and the proliferative control of normal cells.

MAPRE2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 347 amino acids (1-327 a.a.) and having a molecular mass of 39.2kDa.MAPRE2 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:RP1: shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. Its function is unknown; however, its homology suggests involvement in tumorigenesis of colorectal cancers and proliferative control of normal cells. This gene may belong to the intermediate/early gene family, involved in the signal transduction cascade downstream of the TCR.
UniProt Protein Details:

Protein type:Cytoskeletal

Chromosomal Location of Human Ortholog: 18q12.1

Cellular Component: microtubule cytoskeleton; cytoplasm

Molecular Function:microtubule binding

Biological Process: mitosis; cell proliferation; cell division; signal transduction

NCBI Summary:The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. This protein is a microtubule-associated protein that is necessary for spindle symmetry during mitosis. It is thought to play a role in the tumorigenesis of colorectal cancers and the proliferative control of normal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
UniProt Code:Q15555
NCBI GenInfo Identifier:60390165
NCBI Gene ID:10982
NCBI Accession:Q15555.1
UniProt Secondary Accession:Q15555,Q9UQ33, B2RE21, B3KR39, B4DJV4, B7Z2L3, E9PHR3 F5H1V8, G5E9I6,
UniProt Related Accession:Q15555
Molecular Weight:327
NCBI Full Name:Microtubule-associated protein RP/EB family member 2
NCBI Synonym Full Names:microtubule-associated protein, RP/EB family, member 2
NCBI Official Symbol:MAPRE2��
NCBI Official Synonym Symbols:EB1; EB2; RP1��
NCBI Protein Information:microtubule-associated protein RP/EB family member 2; end-binding protein 2; APC-binding protein EB1; APC-binding protein EB2; T-cell activation protein, EB1 family
UniProt Protein Name:Microtubule-associated protein RP/EB family member 2
UniProt Synonym Protein Names:APC-binding protein EB2; End-binding protein 2; EB2
Protein Family:Microtubule-associated protein RP/EB family
UniProt Gene Name:MAPRE2��
UniProt Entry Name:MARE2_HUMAN
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