Human MAPKSP1 Recombinant Protein (RPPB3924)

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RPPB3924

Description

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Product Name:Human MAPKSP1 Recombinant Protein
Product Code:RPPB3924
Size:20µg
Species:Human
Target:MAPKSP1
Synonyms:MAPBP, MP1, MAPK Scaffold Protein 1, Interacting Protein 1, MEK binding partner 1, Mitogen-Activated Protein Kinase kinase 1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The MAPKSP1 protein solution (0.5mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0) 5mM DTT, 100mM NaCl and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.Please avoid freeze thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MADDLKRFLY KKLPSVEGLH AIVVSDRDGV PVIKVANDNA PEHALRPGFL STFALATDQG SKLGLSKNKS IICYYNTYQV VQFNRLPLVV SFIASSSANT GLIVSLEKEL APLFEELRQV VEVS

MAPKSP1 is a scaffold protein which operates in the extracellular signal-regulated kinase (ERK) cascade. MAPKSP1 protein is restricted to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2.

MAPKSP1 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 144 amino acids (1-124a.a.) and having a molecular mass of 15.8kDa.MAPKSP1 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:LAMTOR3: Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, recruits the Rag GTPases and the mTORC1 complex to lysosomes, a key step in activation of the TOR signaling cascade by amino acids. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2. Interacts with MAP2K1/MEK1 and MAPK2. Interacts with MORG1. Part of the Ragulator complex composed of LAMTOR1, LAMTOR2 and LAMTOR3. Interacts with LAMTOR1; the interaction is direct. Belongs to the LAMTOR3 family.Protein type: Adaptor/scaffoldChromosomal Location of Human Ortholog: 4q23Cellular Component: focal adhesionMolecular Function: protein binding; guanyl-nucleotide exchange factor activity; protein complex scaffoldBiological Process: positive regulation of TOR signaling pathway; positive regulation of GTPase activity
UniProt Protein Details:
NCBI Summary:This gene encodes a scaffold protein that functions in the extracellular signal-regulated kinase (ERK) cascade. The protein is localized to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. Studies of the orthologous gene in mouse indicate that it regulates late endosomal traffic and cell proliferation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 13. [provided by RefSeq, Aug 2011]
UniProt Code:Q9UHA4
NCBI GenInfo Identifier:24418562
NCBI Gene ID:8649
NCBI Accession:Q9UHA4.1
UniProt Secondary Accession:Q9UHA4,Q9H364, B2R4A1, J3KMX4
UniProt Related Accession:Q9UHA4
Molecular Weight:124
NCBI Full Name:Ragulator complex protein LAMTOR3
NCBI Synonym Full Names:late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
NCBI Official Symbol:LAMTOR3��
NCBI Official Synonym Symbols:MP1; MAPBP; MAPKSP1; PRO0633; MAP2K1IP1; Ragulator3��
NCBI Protein Information:ragulator complex protein LAMTOR3; MEK binding partner 1; MAPK scaffold protein 1; mitogen-activated protein kinase scaffold protein 1; late endosomal/lysosomal adaptor and MAPK and MTOR activator 3; mitogen-activated protein kinase kinase 1 interacting p
UniProt Protein Name:Ragulator complex protein LAMTOR3
UniProt Synonym Protein Names:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3; MEK-binding partner 1; Mp1; Mitogen-activated protein kinase kinase 1-interacting protein 1; Mitogen-activated protein kinase scaffold protein 1
Protein Family:
UniProt Gene Name:LAMTOR3��
UniProt Entry Name:LTOR3_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9UHA4
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