Description
| Product Name: | Human MAOA Recombinant Protein |
| Product Code: | RPPB1921 |
| Size: | 20µg |
| Species: | Human |
| Target: | MAOA |
| Synonyms: | Monoamine Oxidase A, Monoamine Oxidase Type A, EC 1.4.3.4,MAO-A, Amine Oxidase [Flavin-Containing] A, EC 1.4.3, Amine oxidase[flavin-containing] A, Monoamine oxidase type A. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | MAOAprotein solution (0.5mg/ml) containing 20mM Tris-HCl (pH8.0) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 80% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMENQEKA SIAGHMFDVV VIGGGISGLS AAKLLTEYGV SVLVLEARDRVGGRTYTIRN EHVDYVDVGG AYVGPTQNRI LRLSKELGIE TYKVNVSERL VQYVKGKTYP FRGAFPPVWNPIAYLDYNNL WRTIDNMGKE IPTDAPWEAQ HADKWDKMTM KELIDKICWT KTARRFAYLF VNINVTSEPHEVSALWFLWY VKQCGGTTRI FSVTNGGQER KFVGGSGQVS ERIMDLLGDQ VKLNHPVTHV DQSSDNIIIETLNHEHYECK YVINAIPPTL TAKIHFRPEL PAERNQLIQR LPMGAVIKCM MYYKEAFWKK KDYCGCMIIEDEDAPISITL DDTKPDGSLP AIMGFILARK ADRLAKLHKE IRKKKICELY AKVLGSQEAL HPVHYEEKNWCEEQYSGGCY TAYFPPGIMT QYGRVIRQPV GRIFFAGTET ATKWSGYMEG AVEAGERAAR EVLNGLGKVTEKDIWVQEPE SKDVPAVEIT HTFWERNLPS |
Monoamine Oxidase A, also known as MAOA catalyzes the oxidative deamination of biogenic as well as xenobiotic amines and has significant functions in the metabolism of neuroactive and vasoactive amines in the central nervous system as well as peripheral tissues. Mutation in MAOA results in Brunner syndrome; in addition MAOA has also been linked with a diversity of other psychiatric disorders, which includes antisocial behavior. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT).
MAOA Human Recombinant produced in E.Coli is a single, non-glycosylatedpolypeptide chain containing 520 amino acids (1-497 a.a) and having a molecularmass of 58.8kDa.�MAOA is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | MAOA: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine. Defects in MAOA are the cause of Brunner syndrome (BRUNS). Brunner syndrome is a form of X-linked non- dysmorphic mild mental retardation. Male patients are affected by a syndrome of borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior. Belongs to the flavin monoamine oxidase family. |
| UniProt Protein Details: | Protein type:EC 1.4.3.4; Membrane protein, integral; Amino Acid Metabolism - tryptophan; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Amino Acid Metabolism - histidine; Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - glycine, serine and threonine; Oxidoreductase; Amino Acid Metabolism - tyrosine Chromosomal Location of Human Ortholog: Xp11.3 Cellular Component: mitochondrial outer membrane; mitochondrion; integral to membrane Molecular Function:amine oxidase activity Biological Process: synaptic transmission; biogenic amine metabolic process; neurotransmitter catabolic process; dopamine catabolic process; xenobiotic metabolic process; neurotransmitter secretion; neurotransmitter biosynthetic process Disease: Brunner Syndrome |
| NCBI Summary: | This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012] |
| UniProt Code: | P21397 |
| NCBI GenInfo Identifier: | 113978 |
| NCBI Gene ID: | 4128 |
| NCBI Accession: | P21397.1 |
| UniProt Secondary Accession: | P21397,Q16426, B4DF46, |
| UniProt Related Accession: | P21397 |
| Molecular Weight: | 527 |
| NCBI Full Name: | Amine oxidase |
| NCBI Synonym Full Names: | monoamine oxidase A |
| NCBI Official Symbol: | MAOA�� |
| NCBI Official Synonym Symbols: | MAO-A�� |
| NCBI Protein Information: | amine oxidase [flavin-containing] A; amine oxidase [flavin-containing] A; monoamine oxidase type A |
| UniProt Protein Name: | Amine oxidase [flavin-containing] A |
| UniProt Synonym Protein Names: | Monoamine oxidase type A; MAO-A |
| Protein Family: | Amine oxidase |
| UniProt Gene Name: | MAOA�� |
| UniProt Entry Name: | AOFA_HUMAN |
