Enzymes Recombinant Proteins

Human MAO B Recombinant Protein (RPPB1922)

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SKU:
RPPB1922
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P27338
Research Area:
Enzymes

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human MAO B Recombinant Protein
Product Code:RPPB1922
Size:10µg
Species:Human
Target:MAO B
Synonyms:Amine oxidase [flavin-containing] B, Monoamine oxidase type B, MAO-B, MAOB, MGC26382.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:MAO-B protein is supplied in 20mM Tris-HCl, pH 8.0, 250mM NaCl, 1mM EDTA and 50% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.

MAO-B is a member of the flavin monoamine oxidase family. MAO-B (Monoamine oxidase B) is a flavin-containing mitochondrial enzyme that catalyzes the oxidative deamination of biogenic and xenobiotic monoamines. MAO-B controls the metabolic degradation of catecholamines and serotonin in neural and other target tissues. MAO-B is located in platelets and in DOPA-secreting neurons in the brain. MAOB and MAOA genes have an imperative function in DOPA degradation. Benzylamine and phenylethylamine are preferentially degraded by MAOB. The MAOB gene is linked to autistic traits, empathy and Asperger syndrome. Amplified levels of MAO B are identified in the brain of Alzheimer�s patients. High phenylethylamine levels in neonates as a result of low MAOB are consistent with phenylketonuria in newborns. Polymorphisms in MAO-B are connected to smoking behavior.

MAO-B Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 488 amino acids fragment (2-489) corresponding to the cytoplasmic domain fragment of the mature protein, having a total molecular mass of 59.84kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. The MAO-B is purified by proprietary chromatographic techniques.

UniProt Protein Function:MAOB: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine. Belongs to the flavin monoamine oxidase family.
UniProt Protein Details:

Protein type:Mitochondrial; Amino Acid Metabolism - arginine and proline; EC 1.4.3.4; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - glycine, serine and threonine; Amino Acid Metabolism - histidine; Membrane protein, integral; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Oxidoreductase; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tryptophan

Chromosomal Location of Human Ortholog: Xp11.23

Cellular Component: mitochondrial envelope; mitochondrial outer membrane; mitochondrion; mitochondrial inner membrane; integral to membrane

Molecular Function:amine oxidase activity; protein homodimerization activity; electron carrier activity; FAD binding

Biological Process: response to drug; negative regulation of serotonin secretion; positive regulation of dopamine metabolic process; response to selenium ion; response to ethanol; substantia nigra development; dopamine catabolic process; response to toxin; xenobiotic metabolic process; response to lipopolysaccharide; hydrogen peroxide biosynthetic process; response to corticosterone stimulus; response to aluminum ion

NCBI Summary:The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. [provided by RefSeq, Jul 2008]
UniProt Code:P27338
NCBI GenInfo Identifier:113980
NCBI Gene ID:4129
NCBI Accession:P27338.3
UniProt Secondary Accession:P27338,Q7Z6S2, B2R6R3, B7Z5H3, D3DWC3,
UniProt Related Accession:P27338
Molecular Weight:520
NCBI Full Name:Amine oxidase
NCBI Synonym Full Names:monoamine oxidase B
NCBI Official Symbol:MAOB��
NCBI Protein Information:amine oxidase [flavin-containing] B; amine oxidase [flavin-containing] B; MAO-B; MAO, brain; MAO, platelet; tyramine oxidase; adrenalin oxidase; monoamine oxidase type B
UniProt Protein Name:Amine oxidase [flavin-containing] B
UniProt Synonym Protein Names:Monoamine oxidase type B; MAO-B
Protein Family:Amine oxidase
UniProt Gene Name:MAOB��
UniProt Entry Name:AOFB_HUMAN
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