Human MAFK Recombinant Protein (RPPB3909)
- SKU:
- RPPB3909
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O60675
Description
| Product Name: | Human MAFK Recombinant Protein |
| Product Code: | RPPB3909 |
| Size: | 20µg |
| Species: | Human |
| Target: | MAFK |
| Synonyms: | NFE2U, P18, Erythroid transcription factor NF-E2 p18 subunit, MAFK, Transcription factor MafK. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | MAFK protein solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MTTNPKPNKA LKVKKEAGEN APVLSDDELV SMSVRELNQH LRGLTKEEVT RLKQRRRTLK NRGYAASCRI KRVTQKEELE RQRVELQQEV EKLARENSSM RLELDALRSK YEALQTFART VARGPVAPSK VATTSVITIV KSTELSSTSV PFSAAS |
MAFK is a member of the bZIP family and Maf subfamily. Members from Maf family of basic region/leucine zipper (bZIP) transcription factors influence transcription in a positive or negative way, depending on their protein associate and the context of the target promoter. Small Mafs act as transcriptional repressors when they dimerize among themselves. Yet, they seem to function as transcriptional activators by dimerizing with other basic-zipper proteins and employing them to specific DNA-binding sites.
MAFK Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 176 amino acids (1-156 a.a.) and having a molecular mass of 19.7kDa.MAFK is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | MAFK: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Belongs to the bZIP family. Maf subfamily. |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 7p22.3 Cellular Component: nucleoplasm Molecular Function:transcription factor activity Biological Process: nervous system development; transcription, DNA-dependent; regulation of transcription, DNA-dependent; blood coagulation |
| NCBI Summary: | The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 612386). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites.[supplied by OMIM, Nov 2008] |
| UniProt Code: | O60675 |
| NCBI GenInfo Identifier: | 4505075 |
| NCBI Gene ID: | 7975 |
| NCBI Accession: | NP_002351.1 |
| UniProt Secondary Accession: | O60675,A4D214, |
| UniProt Related Accession: | O60675 |
| Molecular Weight: | 17,523 Da |
| NCBI Full Name: | transcription factor MafK |
| NCBI Synonym Full Names: | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K |
| NCBI Official Symbol: | MAFK�� |
| NCBI Official Synonym Symbols: | P18; NFE2U�� |
| NCBI Protein Information: | transcription factor MafK; nuclear factor erythroid-2, ubiquitous (p18); basic-leucine zipper transcription factor MafK; erythroid transcription factor NF-E2 p18 subunit; v-maf musculoaponeurotic fibrosarcoma oncogene homolog K; v-maf avian musculoaponeurotic fibrosarcoma oncogene family, protein K |
| UniProt Protein Name: | Transcription factor MafK |
| UniProt Synonym Protein Names: | Erythroid transcription factor NF-E2 p18 subunit |
| Protein Family: | Transcription factor |
| UniProt Gene Name: | MAFK�� |
| UniProt Entry Name: | MAFK_HUMAN |
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