Human MAF1 Recombinant Protein (RPPB3906)
- SKU:
- RPPB3906
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9H063
Description
| Product Name: | Human MAF1 Recombinant Protein |
| Product Code: | RPPB3906 |
| Size: | 20µg |
| Species: | Human |
| Target: | MAF1 |
| Synonyms: | MAF1 homolog (S. cerevisiae), Repressor of RNA polymerase III transcription MAF1 homolog, homolog of yeast MAF1, MGC20332, MGC31779, MGC39758, DKFZp586G1123. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The MAF1 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MKLLENSSFE AINSQLTVET GDAHIIGRIE SYSCKMAGDD KHMFKQFCQE GQPHVLEALS PPQTSGLSPS RLSKSQGGEE EGPLSDKCSR KTLFYLIATL NESFRPDYDF STARSHEFSR EPSLSWVVNA VNCSLFSAVR EDFKDLKPQL WNAVDEEICL AECDIYSYNP DLDSDPFGED GSLWSFNYFF YNKRLKRIVF FSCRSISGST YTPSEAGNEL DMELGEEEVE EESRSRGSGA EETSTMEEDR VPVICI |
MAF1 resembles Maf1 which is a Saccharomyces cerevisiae � a highly conserved protein in eukaryotic cells, localized to the nucleus. MAF1 Interacts with BRF2, MAF1 and functions as a mediator for signals which explicitly inhibit RNA polymerase III (Pol III) activity by inhibiting the association of TFIIIB to DNA. MAF1 reacts to modifications in the cellular environment and represses pol III transcription.
MAF1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 276 amino acids (1-256) and having a molecular mass of 31.0 kDa.The MAF1 is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | MAF1: Element of the mTORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA. Belongs to the MAF1 family. |
| UniProt Protein Details: | Protein type:Transcription regulation Chromosomal Location of Human Ortholog: 8q24.3 Cellular Component: nucleoplasm; centrosome; intracellular membrane-bound organelle; axon; dendrite; cytoplasm; plasma membrane; nucleolus; intracellular; nucleus; cytosol Biological Process: transcription, DNA-dependent; negative regulation of transcription from RNA polymerase III promoter |
| UniProt Code: | Q9H063 |
| NCBI GenInfo Identifier: | 49065352 |
| NCBI Gene ID: | |
| NCBI Accession: | CAG38494.1 |
| UniProt Secondary Accession: | Q9H063,D3DWL4, |
| Molecular Weight: | 28,771 Da |
| NCBI Full Name: | MAF1 |
| UniProt Protein Name: | Repressor of RNA polymerase III transcription MAF1 homolog |
| Protein Family: | Maf-like protein |
| UniProt Gene Name: | MAF1�� |
| UniProt Entry Name: | MAF1_HUMAN |
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