Human MAEA Recombinant Protein (RPPB3905)
- SKU:
- RPPB3905
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q7L5Y9
Description
| Product Name: | Human MAEA Recombinant Protein |
| Product Code: | RPPB3905 |
| Size: | 10µg |
| Species: | Human |
| Target: | MAEA |
| Synonyms: | Macrophage Erythroblast Attacher, GID Complex Subunit 9 FYV10 Homolog, Lung Cancer-Related Protein 10, Proliferation-Inducing Gene 5, Human Lung Cancer Oncogene 10 Protein, Cell Proliferation-Inducing Gene 5 Protein, Erythroblast Macrophage Protein, FYV10 Homolog (S. Cerevisiae), GID Complex Subunit 9, EMLP, GID9, PIG5, HLC-10, EMP. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The MAEA solution contains 20mM Tris-HCl buffer (pH 8.0), 1M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAVQESA AQLSMTLKVQ EYPTLKVPYE TLNKRFRAAQ KNIDRETSHV TMVVAELEKT LSGCPAVDSV VSLLDGVVEK LSVLKRKAVE SIQAEDESAK LCKRRIEHLK EHSSDQPAAA SVWKRKRMDR MMVEHLLRCG YYNTAVKLAR QSGIEDLVNI EMFLTAKEVE ESLERRETAT CLAWCHDNKS RLRKMKSCLE FSLRIQEFIE LIRQNKRLDA VRHARKHFSQ AEGSQLDEVR QAMGMLAFPP DTHISPYKDL LDPARWRMLI QQFRYDNYRL HQLGNNSVFT LTLQAGLSAI KTPQCYKEDG SSKSPDCPVC SRSLNKLAQP LPMAHCANSR LVCKISGDVM NENNPPMMLP NGYVYGYNSL LSIRQDDKVV CPRTKEVFHF SQAEKVYIM |
MAEA is a 396aa widely expressed adhesion protein which has 5 alternatively spliced isoforms. MAEA holds one CTLH domain and one LisH domain. MAEA forms a complex with F-actin, which takes part in regulating actin distribution in erythroblasts and macrophages and is known to assist in cell division and nuclear architecture. MAEA is confined with condensed chromatin at prophase, nuclear spindle poles at metaphase and in the contractile ring throughout cytokinesis phase and telophase.
MAEA Human Recombinant (isoform 1) produced in E.coli is a single, non-glycosylated polypeptide chain containing 419 amino acids (1-396) and having a molecular mass of 47.7kDa.MAEA is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | MAEA: Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cell adhesion; Actin-binding; Cell development/differentiation Chromosomal Location of Human Ortholog: 4p16.3 Cellular Component: contractile ring; cytoplasm; cytoskeleton; integral to plasma membrane; nuclear matrix; nucleus; spindle Molecular Function:actin binding Biological Process: cell adhesion; negative regulation of myeloid cell apoptosis |
| NCBI Summary: | This gene encodes a protein that mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal maturation and enucleation of erythroblasts, presumably by suppressing apoptosis. The encoded protein is an integral membrane protein with the N-terminus on the extracellular side and the C-terminus on the cytoplasmic side of the cell. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014] |
| UniProt Code: | Q7L5Y9 |
| NCBI GenInfo Identifier: | 74754297 |
| NCBI Gene ID: | 10296 |
| NCBI Accession: | Q7L5Y9.1 |
| UniProt Secondary Accession: | Q7L5Y9,O95285, Q5JB54, Q6ZRD6, Q9BQ11, Q9H9V6, Q9H9Z4 Q9NW84, |
| UniProt Related Accession: | Q7L5Y9 |
| Molecular Weight: | 26,802 Da |
| NCBI Full Name: | Macrophage erythroblast attacher |
| NCBI Synonym Full Names: | macrophage erythroblast attacher |
| NCBI Official Symbol: | MAEA�� |
| NCBI Official Synonym Symbols: | EMP; EMLP; GID9; PIG5; HLC-10�� |
| NCBI Protein Information: | macrophage erythroblast attacher |
| UniProt Protein Name: | Macrophage erythroblast attacher |
| UniProt Synonym Protein Names: | Cell proliferation-inducing gene 5 protein; Erythroblast macrophage protein; Human lung cancer oncogene 10 protein; HLC-10 |
| Protein Family: | Macrophage erythroblast attacher |
| UniProt Gene Name: | MAEA�� |
| UniProt Entry Name: | MAEA_HUMAN |
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