Human MAD2L1BP Recombinant Protein (RPPB3904)

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RPPB3904

Description

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Product Name:Human MAD2L1BP Recombinant Protein
Product Code:RPPB3904
Size:10µg
Species:Human
Target:MAD2L1BP
Synonyms:MAD2L1-binding protein, Caught by MAD2 protein, MAD2L1BP, CMT2, KIAA0110, RP1-261G23.6.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:MAD2L1BP protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 10% glycerol and 100mM NaCl.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMAAPEA EVLSSAAVPD LEWYEKSEET HASQIELLET SSTQEPLNAS EAFCPRDCMV PVVFPGPVSQ EGCCQFTCEL LKHIMYQRQQ LPLPYEQLKH FYRKPSPQAE EMLKKKPRAT TEVSSRKCQQ ALAELESVLS HLEDFFARTL VPRVLILLGGNALSPKEFYE LDLSLLAPYS VDQSLSTAAC LRRLFRAIFM ADAFSELQAP PLMGTVVMAQ GHRNCGEDWF RPKLNYRVPS RGHKLTVTLS CGRPSIRTTA WEDYIWFQAP VTFKGFRE

MAD2L1-binding protein (MAD2L1BP) is a member of the MAD2L1BP family.MAD2L1BP is a binding protein of the MAD2 mitotic arrest deficient-like 1 (MAD2/MAD2L1). MAD2 is a fundamental factor of the spindle checkpoint which delays the onset of anaphase until all the kinetochores are connected to the spindle. The MAD2L1BP protein acts to curb the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 once it dissociated from the MAD2L1-CDC20 complex. For the duration of the cell cycle, MAD2L1BP levels increase and then remain constant until late mitosis after which they drop.

MAD2L1BP Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 298 amino acids (1-274 a.a) and having a molecular mass of 33.6kDa (Molecular weight on SDS-PAGE will appear higher).MAD2L1BP is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:MAD2L1BP: May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex. Belongs to the MAD2L1BP family.Protein type: Cell cycle regulationChromosomal Location of Human Ortholog: 6p21.1Cellular Component: cytoplasm; nucleusMolecular Function: protein bindingBiological Process: mitotic cell cycle checkpoint; regulation of exit from mitosis
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene was identified as a binding protein of the MAD2 mitotic arrest deficient-like 1 (MAD2/MAD2L1). MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached to the spindle. This protein may interact with the spindle checkpoint and coordinate cell cycle events in late mitosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
UniProt Code:Q15013
NCBI GenInfo Identifier:3123048
NCBI Gene ID:9587
NCBI Accession:Q15013.1
UniProt Secondary Accession:Q15013,Q6IBB1, B4DLV3, E9PAT7
UniProt Related Accession:Q15013
Molecular Weight:34,676 Da
NCBI Full Name:MAD2L1-binding protein
NCBI Synonym Full Names:MAD2L1 binding protein
NCBI Official Symbol:MAD2L1BP��
NCBI Official Synonym Symbols:CMT2��
NCBI Protein Information:MAD2L1-binding protein
UniProt Protein Name:MAD2L1-binding protein
UniProt Synonym Protein Names:Caught by MAD2 protein
Protein Family:MAD2L1-binding protein
UniProt Gene Name:MAD2L1BP��
UniProt Entry Name:MD2BP_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q15013
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