Human M6PR Recombinant Protein (RPPB3900)

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SKU:
RPPB3900
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P20645

Description

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Product Name:Human M6PR Recombinant Protein
Product Code:RPPB3900
Size:10µg
Species:Human
Target:M6PR
Synonyms:Mannose-6-Phosphate Receptor (Cation Dependent), CD-MPR, MPR46, CD Man-6-P Receptor, MPR 46, 46-KDa Mannose 6-Phosphate Receptor, MPR-46, SMPR, Cation-Dependent Mannose-6-Phosphate Receptor, Mr 46,000 Man6PR, Small Mannose 6-Phosphate Receptor, 46 KDa Mannose 6-Phosphate Receptor, MPRD, M6PR.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The M6PR solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSTEEKTCD LVGEKGKESE KELALVKRLK PLFNKSFEST VGQGSDTYIY IFRVCREAGN HTSGAGLVQI NKSNGKETVV GRLNETHIFN GSNWIMLIYK GGDEYDNHCG KEQRRAVVMI SCNRHTLADN FNPVSEERGK VQDCFYLFEM DSSLACSPEI SH

Mannose-6-Phosphate Receptor (M6PR) belongs to the P-type lectin family. P-type lectins play a vital role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The M6PR protein functions as a homodimer and needs divalent cations for ligand binding. Lysosomal enzymes carrying phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the ensuing receptor-ligand complex is transferred to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.

M6PR Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 182 amino acids (27-185) and having a molecular mass of 20.3kDa.M6PR is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:M6PR: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: endosome; integral to plasma membrane; membrane; perinuclear region of cytoplasm; trans-Golgi network; trans-Golgi network membrane; transport vesicle

Molecular Function:transmembrane receptor activity

Biological Process: endosome to lysosome transport; receptor-mediated endocytosis

NCBI Summary:This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011]
UniProt Code:P20645
NCBI GenInfo Identifier:127293
NCBI Gene ID:4074
NCBI Accession:P20645.1
UniProt Secondary Accession:P20645,A8K528, D3DUV5,
UniProt Related Accession:P20645
Molecular Weight:30,993 Da
NCBI Full Name:Cation-dependent mannose-6-phosphate receptor
NCBI Synonym Full Names:mannose-6-phosphate receptor, cation dependent
NCBI Official Symbol:M6PR��
NCBI Official Synonym Symbols:SMPR; MPR46; CD-MPR; MPR 46; MPR-46; CD-M6PR��
NCBI Protein Information:cation-dependent mannose-6-phosphate receptor
UniProt Protein Name:Cation-dependent mannose-6-phosphate receptor
UniProt Synonym Protein Names:46 kDa mannose 6-phosphate receptor; MPR 46
Protein Family:Cation-dependent mannose-6-phosphate receptor
UniProt Gene Name:M6PR��
UniProt Entry Name:MPRD_HUMAN
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