Human LZTFL1 Recombinant Protein (RPPB3899)
- SKU:
- RPPB3899
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9NQ48
Description
| Product Name: | Human LZTFL1 Recombinant Protein |
| Product Code: | RPPB3899 |
| Size: | 20µg |
| Species: | Human |
| Target: | LZTFL1 |
| Synonyms: | Leucine Zipper Transcription Factor-Like 1, BBS17, LeucineZipper Transcription Factor-Like Protein 1, Leucine zipper transcriptionfactor-like protein 1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | LZTFL1 protein solution (1mg/ml) containing PBS buffer(pH 7.4), 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAELGLN EHHQNEVINY MRFARSKRGL RLKTVDSCFQ DLKESRLVEDTFTIDEVSEV LNGLQAVVHS EVESELINTA YTNVLLLRQL FAQAEKWYLK LQTDISELEN RELLEQVAEFEKAEITSSNK KPILDVTKPK LAPLNEGGTA ELLNKEILRL QEENEKLKSR LKTIEIQATN ALDEKSKLEKALQDLQLDQG NQKDFIKAQD LSNLENTVAA LKSEFQKTLN DKTENQKSLE ENLATAKHDL LRVQEQLHMAEKELEKKFQQ TAAYRNMKEI LTKKNDQIKD LRKRLAQYEP ED |
LeucineZipper Transcription Factor-Like 1, also known as LZTFL1 is a ubiquitouslyexpressed protein which localizes to the cytoplasm. LZTFL1 interacts with Bardet-BiedlSyndrome proteins (BBS) and during its interaction with BBS protein complexes,regulates protein trafficking to the ciliary membrane. Nonsense mutations inLZTFL1 cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized partlyby polydactyly, obesity, cognitive impairment, hypogonadism, and� kidney failure. LZTFL1 also acts as a tumorsuppressor; possibly by interacting with E-cadherin as well as the actin cytoskeletonand in this manner regulating the transition of epithelial cells to mesenchymalcells.
LZTFL1 Human Recombinant produced in E.Coli is a single, non-glycosylatedpolypeptide chain containing 322 amino acids (1-299 a.a) and having a molecularmass of 37.0kDa.LZTFL1 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | LZTFL1: Belongs to the LZTFL1 family.Chromosomal Location of Human Ortholog: 3p21.3Cellular Component: cytosolMolecular Function: identical protein binding; protein binding; protein complex bindingDisease: Bardet-biedl Syndrome 17 |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in this gene cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. This gene may also function as a tumor suppressor; possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2013] |
| UniProt Code: | Q9NQ48 |
| NCBI GenInfo Identifier: | 74734310 |
| NCBI Gene ID: | 54585 |
| NCBI Accession: | Q9NQ48.1 |
| UniProt Secondary Accession: | Q9NQ48,Q8TC61, Q9NQ56, B3KSI9, B4E0K7 |
| UniProt Related Accession: | Q9NQ48 |
| Molecular Weight: | 29,332 Da |
| NCBI Full Name: | Leucine zipper transcription factor-like protein 1 |
| NCBI Synonym Full Names: | leucine zipper transcription factor like 1 |
| NCBI Official Symbol: | LZTFL1�� |
| NCBI Official Synonym Symbols: | BBS17�� |
| NCBI Protein Information: | leucine zipper transcription factor-like protein 1 |
| UniProt Protein Name: | Leucine zipper transcription factor-like protein 1 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Leucine zipper transcription factor-like protein |
| UniProt Gene Name: | LZTFL1�� |
| UniProt Entry Name: | LZTL1_HUMAN |
Related Products
Human TGFB1 Recombinant Recombinant Protein (RPPB0968)
Growth Factors & Cytokines Recombinant Proteins
Human RNAS2 Recombinant Protein
Human CRP Recombinant Recombinant Protein (RPPB3262)
Human B2M Recombinant Recombinant Protein (RPPB2842)
Human Recombinant Protein S100P Recombinant Protein (His Tag) (RPES5309)
Human Acrp30 Protein Recombinant Protein (RPPB5717)
Cytokines Recombinant Proteins
