Enzymes Recombinant Proteins

Human LYVE1 Recombinant Protein (RPPB2561)

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SKU:
RPPB2561
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9Y5Y7
Research Area:
Enzymes

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human LYVE1 Recombinant Protein
Product Code:RPPB2561
Size:10µg
Species:Human
Target:LYVE1
Synonyms:Lymphatic vessel endothelial hyaluronic acid receptor 1 precursor, LYVE-1, Cell surface retention sequence-binding protein 1, CRSBP-1, Hyaluronic acid receptor, Extracellular link domain-containing protein 1.
Source:Insect Cells
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:LYVE1 was lyophilized from a concentrated (1 mg/ml) sterile solution containing no additives.
Solubility:It is recommended to reconstitute the lyophilized LYVE1 in sterile water not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized sLYVE-1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution sLYVE-1 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 95.0% as determined by(a)Analysis by RP-HPLC.(b)Analysis by SDS-PAGE.

LYVE-1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE-1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE-1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE-1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves.

Soluble LYVE1 Human Recombinant fused to a C-terminal His-tag (6xHis) produced in baculovirus is a monomeric, glycosylated, polypeptide containing 232 amino acids (Met-1 to Gly 232) and having a total molecular mass of 25 kDa but as a result of glycosilation the Mw is 40 kDa. The LYVE-1 is purified by proprietary chromatographic techniques.

UniProt Protein Function:XLKD1: Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as an hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.
UniProt Protein Details:

Protein type:Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 11p15

Cellular Component: membrane; integral to plasma membrane; plasma membrane

Molecular Function:transmembrane receptor activity; hyaluronic acid binding; receptor activity

Biological Process: anatomical structure morphogenesis; glycosaminoglycan metabolic process; transport; cell-matrix adhesion; carbohydrate metabolic process; response to wounding; pathogenesis; signal transduction; cell motility; hyaluronan metabolic process; hyaluronan catabolic process

NCBI Summary:This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. [provided by RefSeq, Jul 2008]
UniProt Code:Q9Y5Y7
NCBI GenInfo Identifier:115502898
NCBI Gene ID:10894
NCBI Accession:Q9Y5Y7.2
UniProt Secondary Accession:Q9Y5Y7,Q8TC18, Q9UNF4,
UniProt Related Accession:Q9Y5Y7
Molecular Weight:35,213 Da
NCBI Full Name:Lymphatic vessel endothelial hyaluronic acid receptor 1
NCBI Synonym Full Names:lymphatic vessel endothelial hyaluronan receptor 1
NCBI Official Symbol:LYVE1��
NCBI Official Synonym Symbols:HAR; XLKD1; LYVE-1; CRSBP-1��
NCBI Protein Information:lymphatic vessel endothelial hyaluronic acid receptor 1; cell surface retention sequence binding protein-1; cell surface retention sequence-binding protein 1; extracellular link domain containing 1; extracellular link domain-containing 1; extracellular link domain-containing protein 1
UniProt Protein Name:Lymphatic vessel endothelial hyaluronic acid receptor 1
UniProt Synonym Protein Names:Cell surface retention sequence-binding protein 1; CRSBP-1; Extracellular link domain-containing protein 1; Hyaluronic acid receptor
Protein Family:Lymphatic vessel endothelial hyaluronic acid receptor
UniProt Gene Name:LYVE1��
UniProt Entry Name:LYVE1_HUMAN
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