Enzymes Recombinant Proteins

Human LYVE1 25-235 a.a. Recombinant Protein (RPPB2560)

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SKU:
RPPB2560
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9Y5Y7
Research Area:
Enzymes

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human LYVE1 25-235 a.a. Recombinant Protein
Product Code:RPPB2560
Size:10µg
Species:Human
Target:LYVE1 25-235 a.a.
Synonyms:HAR, XLKD1, LYVE-1, CRSBP-1, LYVE1, Lymphatic vessel endothelial hyaluronic acid receptor 1 precursor, Cell surface retention sequence-binding protein 1, Hyaluronic acid receptor, Extracellular link domain-containing protein.
Source:Hi-5 cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The LYVE1 protein solution contains 20mM Tris buffer pH-7.5 and 10% Glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:DPLRAEELS IQVSCRIMGI TLVSKKANQQ LNFTEAKEAC RLLGLSLAGK DQVETALKAS FETCSYGWVG DGFVVISRIS PNPKCGKNGV GVLIRKVPVS RQFAAYCYNS SDTWTNSCIP EIITTKDPIF NTQTATQTTE FIVSDSTYSV ASPYSTIPAP TTTPPAPAST SIPRRKKLIC VTEVFMETST MSTETEPFVE NKAAFKNEAA GFGGSGRLVP RGSHHHHHH

LYVE1 is a selective marker of the lymphatic endothelium & a surface endocytic receptor for both soluble and immobilized hyaluronan, LYVE1 is an extracellular glycosaminoglycan that plays a role in cell adhesion and migration. LYVE1 functions in lympathic hyaluronan transport and is involved in tumor metastasis. Recombinant human LYVE1 was expressed in and purified by conventional chromatography techniques. The normal adult human choroid is endowed with a significant number of LYVE-1 positive macrophages. LYVE-1 is expressed in a reticulum cell neoplasm in an axillary lymph node. This reticulum cell sarcoma is a lymphatic sinus lining cell sarcoma which might represent another subtype of reticulum cell sarcomas.LYVE-1 immunohistochemistry is a functional method for detecting lymphatics invaded by cancer cells, and detailed examination of the submucosa around the tumor is important for predicting LN metastasis.

LYVE1 Human Recombinant produced in insect cells is a single, glycosylated polypeptide chain containing 229 amino acids and having a molecular mass of 24.8 kDa. As a result of glycosylation, the LYVE1 migrates on SDS-PAGE at approximately 50 kDa.LYVE1 is expressed with 15 amino acids His tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:XLKD1: Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as an hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.
UniProt Protein Details:

Protein type:Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 11p15

Cellular Component: membrane; integral to plasma membrane; plasma membrane

Molecular Function:transmembrane receptor activity; hyaluronic acid binding; receptor activity

Biological Process: anatomical structure morphogenesis; glycosaminoglycan metabolic process; transport; cell-matrix adhesion; carbohydrate metabolic process; response to wounding; pathogenesis; signal transduction; cell motility; hyaluronan metabolic process; hyaluronan catabolic process

NCBI Summary:This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. [provided by RefSeq, Jul 2008]
UniProt Code:Q9Y5Y7
NCBI GenInfo Identifier:115502898
NCBI Gene ID:10894
NCBI Accession:Q9Y5Y7.2
UniProt Secondary Accession:Q9Y5Y7,Q8TC18, Q9UNF4,
UniProt Related Accession:Q9Y5Y7
Molecular Weight:35,213 Da
NCBI Full Name:Lymphatic vessel endothelial hyaluronic acid receptor 1
NCBI Synonym Full Names:lymphatic vessel endothelial hyaluronan receptor 1
NCBI Official Symbol:LYVE1��
NCBI Official Synonym Symbols:HAR; XLKD1; LYVE-1; CRSBP-1��
NCBI Protein Information:lymphatic vessel endothelial hyaluronic acid receptor 1; cell surface retention sequence binding protein-1; cell surface retention sequence-binding protein 1; extracellular link domain containing 1; extracellular link domain-containing 1; extracellular link domain-containing protein 1
UniProt Protein Name:Lymphatic vessel endothelial hyaluronic acid receptor 1
UniProt Synonym Protein Names:Cell surface retention sequence-binding protein 1; CRSBP-1; Extracellular link domain-containing protein 1; Hyaluronic acid receptor
Protein Family:Lymphatic vessel endothelial hyaluronic acid receptor
UniProt Gene Name:LYVE1��
UniProt Entry Name:LYVE1_HUMAN
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system_update_altDatasheetHuman LYVE1/HAR Recombinant Protein Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1 is a single-pass type I membrane protein. LYVE-1 is a CD44 homolog found prim