Human LY86 Recombinant Protein (RPPB3895)
- SKU:
- RPPB3895
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O95711
Description
| Product Name: | Human LY86 Recombinant Protein |
| Product Code: | RPPB3895 |
| Size: | 20µg |
| Species: | Human |
| Target: | LY86 |
| Synonyms: | Lymphocyte Antigen 86, MD-1 RP105-Associated, Protein MD-1, Ly-86, MMD-1, dJ80N2.1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The LY86 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSGGGGKAW PTHVVCSDSG LEVLYQSCDP LQDFGFSVEK CSKQLKSNIN IRFGIILRED IKELFLDLAL MSQGSSVLNF SYPICEAALP KFSFCGRRKG EQIYYAGPVN NPEFTIPQGE YQVLLELYTE KRSTVACANA TIMCS |
LY86 is vital for effective CD180 cell surface expression and is vastly expressed in B-cells, tonsil and monocytes. LY86 collaborate with TLR4 and CD180 to facilitate the essential immune response to bacterial lipopolysaccharide (LPS) and cytokine production.
LY86 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 165 amino acids (21-162) and having a molecular mass of 18.1kDa.LY86 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | LY86: May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted; Apoptosis Chromosomal Location of Human Ortholog: 6p25.1 Cellular Component: plasma membrane Biological Process: apoptosis; cell proliferation; humoral immune response; positive regulation of lipopolysaccharide-mediated signaling pathway |
| UniProt Code: | O95711 |
| NCBI GenInfo Identifier: | 20138465 |
| NCBI Gene ID: | 9450 |
| NCBI Accession: | O95711.1 |
| UniProt Secondary Accession: | O95711,Q9UQC4, |
| UniProt Related Accession: | O95711 |
| Molecular Weight: | 17,906 Da |
| NCBI Full Name: | Lymphocyte antigen 86 |
| NCBI Synonym Full Names: | lymphocyte antigen 86 |
| NCBI Official Symbol: | LY86�� |
| NCBI Official Synonym Symbols: | MD1; MD-1; MMD-1; dJ80N2.1�� |
| NCBI Protein Information: | lymphocyte antigen 86 |
| UniProt Protein Name: | Lymphocyte antigen 86 |
| UniProt Synonym Protein Names: | Protein MD-1 |
| Protein Family: | Lymphocyte antigen |
| UniProt Gene Name: | LY86�� |
| UniProt Entry Name: | LY86_HUMAN |
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