Cytokines Recombinant Proteins

Human LTBR Recombinant Protein (RPPB0743)

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RPPB0743

Description

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Product Name:Human LTBR Recombinant Protein
Product Code:RPPB0743
Size:10µg
Species:Human
Target:LTBR
Synonyms:Lymphotoxin Beta Receptor (TNFR Superfamily, Member 3), TNFCR,Tumor Necrosis Factor Receptor 2-Related Protein,Tumor Necrosis Factor Receptor Type III, Tumor Necrosis Factor C Receptor,D12S370, TNFRSF3,TNFR3,Tumor Necrosis Factor Receptor Superfamily Member 3,Lymphotoxin-Beta Receptor,Lymphotoxin B Receptor, LT-BETA-R,TNF-R-III, TNFR2-RP, TNF-RIII,TNFR-III, TNFR-RP, CD18, LTBR.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:LTBR protein solution (0.5mg/ml) containing PBS buffer(pH7.4) 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMSQPQAV PPYASENQTC RDQEKEYYEP QHRICCSRCP PGTYVSAKCS RIRDTVCATC AENSYNEHWN YLTICQLCRP CDPVMGLEEI APCTSKRKTQ CRCQPGMFCA AWALECTHCE LLSDCPPGTE AELKDEVGKG NNHCVPCKAG HFQNTSSPSA RCQPHTRCEN QGLVEAAPGT AQSDTTCKNP LEPLPPEMSG TMLM

Lymphotoxin Beta Receptor, also known as LTBRtakes part in signaling during the development of lymphoid and other organs,lipid metabolism, immune response, and programmed cell death. In addition, the activityof this receptor has been associated to carcinogenesis. Alternatively splicedtranscript variants encoding multiple isoforms have been observed for LTBR.

LTBR Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 224 amino acids (28-227 a.a) and having a molecular mass of 24.6kDa.LTBR is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:LTBR: Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p13

Cellular Component: integral to membrane

Molecular Function:identical protein binding; protein binding; ubiquitin protein ligase binding

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; viral reproduction; apoptosis; positive regulation of JNK cascade; myeloid dendritic cell differentiation; signal transduction

NCBI Summary:This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]
UniProt Code:P36941
NCBI GenInfo Identifier:549090
NCBI Gene ID:4055
NCBI Accession:P36941.1
UniProt Secondary Accession:P36941,B7Z1D2, D3DUR2, F5GXE7,
UniProt Related Accession:P36941
Molecular Weight:435
NCBI Full Name:Tumor necrosis factor receptor superfamily member 3
NCBI Synonym Full Names:lymphotoxin beta receptor (TNFR superfamily, member 3)
NCBI Official Symbol:LTBR��
NCBI Official Synonym Symbols:CD18; TNFCR; TNFR3; D12S370; TNFR-RP; TNFRSF3; TNFR2-RP; LT-BETA-R; TNF-R-III��
NCBI Protein Information:tumor necrosis factor receptor superfamily member 3; lymphotoxin B receptor; tumor necrosis factor C receptor; tumor necrosis factor receptor type III; tumor necrosis factor receptor 2-related protein
UniProt Protein Name:Tumor necrosis factor receptor superfamily member 3
UniProt Synonym Protein Names:Lymphotoxin-beta receptor; Tumor necrosis factor C receptor; Tumor necrosis factor receptor 2-related protein; Tumor necrosis factor receptor type III; TNF-RIII; TNFR-III
Protein Family:Tumor necrosis factor receptor superfamily
UniProt Gene Name:LTBR��
UniProt Entry Name:TNR3_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P36941
Research Area:
Cytokines
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