Human LSM5 Recombinant Protein (RPPB3886)

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SKU:
RPPB3886
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9Y4Y9

Description

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Product Name:Human LSM5 Recombinant Protein
Product Code:RPPB3886
Size:20µg
Species:Human
Target:LSM5
Synonyms:LSM5 homolog, U6 small nuclear RNA associated(S.cerevisiae), YER146W, U6 snRNA-associated Sm-like protein LSm5.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:LSM5 protein solution (1mg/ml) containing 20mM Tris-HCl (pH8.5), 10% glycerol, 0.15M NaCl and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMAANATT NPSQLLPLEL VDKCIGSRIH IVMKSDKEIV GTLLGFDDFVNMVLEDVTEF EITPEGRRIT KLDQILLNGN NITMLVPGGE GPEV

LSM5also known as LSM5 Homolog, U6 Small Nuclear RNA Associated belongs to the Smprotein family. This family is identified in a variety of organismsbased on sequence homology. Sm-like proteins contain the Sm sequence motif,which consists of 2 regions separated by a linker of variable length whichfolds as a loop. In addition, the Sm-like proteins are thought to create astable heteromer present in tri-snRNPparticles, which are important for pre-mRNA splicing. Among the diseasesassociated with LSM5 are spinal muscular atrophy, and muscular atrophy.

LSM5 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 114 amino acids (1-91 a.a) and having a molecular mass of 12.3kDa.LSM5 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:LSM5: Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro. Belongs to the snRNP Sm proteins family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: RNA-binding; RNA processingChromosomal Location of Human Ortholog: 7p14.3Cellular Component: cytosol; nucleoplasm; nucleus; spliceosome; U4/U6 x U5 tri-snRNP complexMolecular Function: protein binding; RNA bindingBiological Process: mRNA processing; nuclear mRNA splicing, via spliceosome
UniProt Protein Details:
NCBI Summary:Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]
UniProt Code:Q9Y4Y9
NCBI GenInfo Identifier:6912488
NCBI Gene ID:23658
NCBI Accession:NP_036454.1
UniProt Secondary Accession:Q9Y4Y9
UniProt Related Accession:Q9Y4Y9
Molecular Weight:6,850 Da
NCBI Full Name:U6 snRNA-associated Sm-like protein LSm5 isoform a
NCBI Synonym Full Names:LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
NCBI Official Symbol:LSM5��
NCBI Official Synonym Symbols:YER146W��
NCBI Protein Information:U6 snRNA-associated Sm-like protein LSm5
UniProt Protein Name:U6 snRNA-associated Sm-like protein LSm5
UniProt Synonym Protein Names:
Protein Family:Sm-like protein
UniProt Gene Name:LSM5��
UniProt Entry Name:LSM5_HUMAN
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