Human LSM3 Recombinant Protein (RPPB3884)

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RPPB3884

Description

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Product Name:Human LSM3 Recombinant Protein
Product Code:RPPB3884
Size:20µg
Species:Human
Target:LSM3
Synonyms:LSM3 homolog U6 small nuclear RNA associated (S. cerevisiae), U6 snRNA-associated Sm-like protein LSm3, SMX4, USS2, YLR438C.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The LSM3 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 100mM Nacl, 2mM DTT and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMADDVDQ QQTTNTVEEP LDLIRLSLDE RIYVKMRNDR ELRGRLHAYD QHLNMILGDV EETVTTIEID EETYEEIYKS TKRNIPMLFV RGDGVVLVAP PLRVG

LSM3 is a member of snRNP Sm proteins family which were identified in a large number of organisms based on sequence homology. Sm-like proteins have a Sm sequence motif that holds 2 regions detached by a linker of variable length that fold as a loop. The Sm-like proteins form a stable heteromer found in tri-snRNP particles that are vital for pre-mRNA splicing.

LSM3 Human Recombinant produced in E. coli is a single polypeptide chain containing 125 amino acids (1-102) and having a molecular mass of 14.3kDa.LSM3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:LSM3: Binds specifically to the 3'-terminal U-tract of U6 snRNA. Belongs to the snRNP Sm proteins family.
UniProt Protein Details:

Protein type:Spliceosome; RNA splicing; RNA-binding

Chromosomal Location of Human Ortholog: 3p25.1

Cellular Component: cytosol; nucleus

Molecular Function:protein binding

Biological Process: nuclear mRNA splicing, via spliceosome; gene expression; mRNA processing; mRNA catabolic process, deadenylation-dependent decay

NCBI Summary:Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]
UniProt Code:P62310
NCBI GenInfo Identifier:7657315
NCBI Gene ID:27258
NCBI Accession:NP_055278.1
UniProt Secondary Accession:P62310,Q6IAH0, Q9Y4Z1,
UniProt Related Accession:P62310
Molecular Weight:11,845 Da
NCBI Full Name:U6 snRNA-associated Sm-like protein LSm3
NCBI Synonym Full Names:LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
NCBI Official Symbol:LSM3��
NCBI Official Synonym Symbols:SMX4; USS2; YLR438C��
NCBI Protein Information:U6 snRNA-associated Sm-like protein LSm3
UniProt Protein Name:U6 snRNA-associated Sm-like protein LSm3
Protein Family:U6 snRNA-associated Sm-like protein
UniProt Gene Name:LSM3��
UniProt Entry Name:LSM3_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P62310
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