Human LSM3 Recombinant Protein (RPPB3884)
- SKU:
- RPPB3884
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P62310
Description
| Product Name: | Human LSM3 Recombinant Protein |
| Product Code: | RPPB3884 |
| Size: | 20µg |
| Species: | Human |
| Target: | LSM3 |
| Synonyms: | LSM3 homolog U6 small nuclear RNA associated (S. cerevisiae), U6 snRNA-associated Sm-like protein LSm3, SMX4, USS2, YLR438C. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The LSM3 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 100mM Nacl, 2mM DTT and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMADDVDQ QQTTNTVEEP LDLIRLSLDE RIYVKMRNDR ELRGRLHAYD QHLNMILGDV EETVTTIEID EETYEEIYKS TKRNIPMLFV RGDGVVLVAP PLRVG |
LSM3 is a member of snRNP Sm proteins family which were identified in a large number of organisms based on sequence homology. Sm-like proteins have a Sm sequence motif that holds 2 regions detached by a linker of variable length that fold as a loop. The Sm-like proteins form a stable heteromer found in tri-snRNP particles that are vital for pre-mRNA splicing.
LSM3 Human Recombinant produced in E. coli is a single polypeptide chain containing 125 amino acids (1-102) and having a molecular mass of 14.3kDa.LSM3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | LSM3: Binds specifically to the 3'-terminal U-tract of U6 snRNA. Belongs to the snRNP Sm proteins family. |
| UniProt Protein Details: | Protein type:Spliceosome; RNA splicing; RNA-binding Chromosomal Location of Human Ortholog: 3p25.1 Cellular Component: cytosol; nucleus Molecular Function:protein binding Biological Process: nuclear mRNA splicing, via spliceosome; gene expression; mRNA processing; mRNA catabolic process, deadenylation-dependent decay |
| NCBI Summary: | Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004] |
| UniProt Code: | P62310 |
| NCBI GenInfo Identifier: | 7657315 |
| NCBI Gene ID: | 27258 |
| NCBI Accession: | NP_055278.1 |
| UniProt Secondary Accession: | P62310,Q6IAH0, Q9Y4Z1, |
| UniProt Related Accession: | P62310 |
| Molecular Weight: | 11,845 Da |
| NCBI Full Name: | U6 snRNA-associated Sm-like protein LSm3 |
| NCBI Synonym Full Names: | LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) |
| NCBI Official Symbol: | LSM3�� |
| NCBI Official Synonym Symbols: | SMX4; USS2; YLR438C�� |
| NCBI Protein Information: | U6 snRNA-associated Sm-like protein LSm3 |
| UniProt Protein Name: | U6 snRNA-associated Sm-like protein LSm3 |
| Protein Family: | U6 snRNA-associated Sm-like protein |
| UniProt Gene Name: | LSM3�� |
| UniProt Entry Name: | LSM3_HUMAN |
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