Cell Biology Recombinant Proteins
Human LSAMP Recombinant Protein (RPES3516)
- SKU:
- RPES3516
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Cell Biology
Description
Human LSAMP Recombinant Protein
The limbic system-associated membrane protein (LAMP) is a cell surface glycoprotein expressed by cortical and subcortical regions of the mammalian CNS that comprise or receive direct projections from limbic system structures. The 64-68-kDa glycoprotein limbic system-associated membrane protein (LsAMP) is expressed on the surface of somata and proximal dendrites of neurons. These areas perform cognitive and autonomic functions; also learning and memory. The functional analysis indicates that LsAMP acts as a selective adhesion molecule; serving as a guidance cue for specific patterns of connectivity; which underlies the normal development of the limbic system. In animal studies there have been found that rats with increased level of anxiety had 1.6-fold higher expression of LsAMP gene in the periaqueductal gray compared to rats with low level of anxiety; indicating a possible role of LsAMP in the regulation of anxiety.
| Product Name: | Human LSAMP Recombinant Protein (RPES3516) |
| Product Code: | RPES3516 |
| Size: | 20µg |
| Species: | Human |
| Expressed Host: | HEK293 Cells |
| Synonyms: | FLJ34254,FLJ35396,FLJ37216,FLJ54658,IGLON3,LAMP |
| Accession: | Q13449 |
| Sequence: | Met 1-Asn 315 |
| Fusion tag: | C-Fc |
| Activity: | Measured by its binding ability in a functional ELISA.Immobilized recombinant human OPCML-His at 10 µg/mL can bind recombinant human LSAMP-Fc with a linear range of 31.25-250 ng/ml. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the human LSAMP (Q13449) (Met 1-Asn 315); without the pro peptide; was was fused with the Fc region of human IgG1 at the C-terminus. |
| Purity: | > 97 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 59 kDa |
| AP Mol Mass: | 80-85 kDa |
| Formulation: | Lyophilized from sterile PBS; pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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