Human LRP-6 / Low-density lipoprotein receptor-related protein 6 ELISA Kit

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SKU:
HUFI00871
Product Type:
ELISA Kit
Size:
96 Assays
Uniprot:
O75581
Sensitivity:
0.188ng/ml
Range:
0.313-20ng/ml
ELISA Type:
Sandwich
Synonyms:
LRP6, Low Density Lipoprotein Receptor Related Protein, ADCAD2, low density lipoprotein receptor-related protein 6, LRP-6
Reactivity:
Human
Research Area:
Cell Biology

Description

Human LRP-6 / Low-density lipoprotein receptor-related protein 6 ELISA Kit

LRP-6 protein is a member of the LDL receptor gene family. LDL receptors are membrane proteins that control endocytosis of lipoproteins and protein ligands via receptor-mediated endocytosis. LRP-6 protein is involved in the regulation of cell differentiation, growth, and migration, as well as cancer development. It does so by interacting with the Wnt/beta-catenin signaling pathway. This protein is processed by RIP (regulated intramembrane proteolysis) in the presence of gamma-secretase, however the exact cleavage sites remain unknown. Coronary Artery Disease, Autosomal Dominant 2, and Tooth Agenesis, Selective 7 are examples of LRP6-related disorders. Negative regulation of TCF-dependent signaling by WNT ligand antagonists and the Wnt signaling network are two related processes.

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