Human LRAP/ERAP2 Recombinant Protein (RPES3219)
- SKU:
- RPES3219
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
Human LRAP/ERAP2 Recombinant Protein
Leukocyte-derived arginine aminopeptidase (LRAP), also known as endoplasmic reticulum-aminopeptidase 2 (ERAP2), is the second identified aminopeptidase localized in the in the lumenal side of endoplasmic reticulum (ER) processing antigenic peptides presented to major histocompatibility complex (MHC) class I molecules. It is a 960-amino acid protein with significant homology to placental leucine aminopeptidase and adipocyte-derived leucine aminopeptidase. LRAP preferentially hydrolyzes the basic residues Arg and Lys, and contains the HEXXH(X)18E zinc-binding motif, which is the characteristic of the M1 family of zinc metallopeptidases which also includes PILS/ARTS1/ERAP1 and LNPEP/PLAP. Induced by interferon-gamma, LRAP is able to trim various MHC class I antigenic peptide precursors.
| Product Name: | Human LRAP/ERAP2 Recombinant Protein (RPES3219) |
| Product Code: | RPES3219 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | HEK293 Cells |
| Synonyms: | FLJ23633,FLJ23701,FLJ23807,L-RAP,LRAP,LRAP.ERAP2 |
| Accession: | NP_071745.1 |
| Sequence: | Ala 56-Thr 960 |
| Fusion tag: | N-His |
| Activity: | Measured by its ability to cleave the fluorogenic peptide substrate, Arg-7-amido-4-methylcoumarin (Arg-AMC). The specific activity is >50 pmoles/min/µg. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the lumenal domain of human ERAP2 (NP_071745.1) (Ala 56-Thr 960) was expressed with a polyhistidine tag at the N-terminus. |
| Purity: | > 98 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 106 kDa |
| AP Mol Mass: | 115-125 kDa |
| Formulation: | Lyophilized from sterile 12.5mM Tris, 75mM NaCl, pH 7.5, 50% glycercol |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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