Human LMO1 Recombinant Protein (RPPB3870)

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SKU:
RPPB3870
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P25800

Description

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Product Name:Human LMO1 Recombinant Protein
Product Code:RPPB3870
Size:10µg
Species:Human
Target:LMO1
Synonyms:Rhombotin-1, Cysteine-rich protein TTG-1, LIM domain only protein 1, T-cell translocation protein 1, RBTN1, RHOM1, TTG1, LMO-1, LMO1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:LMO1protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M UREA and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMMVLDKE DGVPMLSVQP KGKQKGCAGC NRKIKDRYLL KALDKYWHED CLKCACCDCR LGEVGSTLYT KANLILCRRD YLRLFGTTGN CAACSKLIPA FEMVMRARDN VYHLDCFACQ LCNQRFCVGD KFFLKNNMIL CQMDYEEGQL NGTFESQVQ

LIM domain only 1 (LMO1) is a protein-coding gene. LMO1 encodes a transcriptional regulator which contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains might play a part in protein interactions; hence the protein may regulate transcription by competitively binding to specific DNA-binding transcription factors.

LMO1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 179 amino acids (1-156 a.a) and having a molecular mass of 20.2kDa.LMO1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:LMO1: May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors. A chromosomal aberration involving LMO1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(11,14)(p15;q11) with TCRD.
UniProt Protein Details:

Protein type:Oncoprotein; DNA-binding

Chromosomal Location of Human Ortholog: 11p15

Cellular Component: nucleus

Molecular Function:zinc ion binding

Biological Process: positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter

NCBI Summary:This locus encodes a transcriptional regulator that contains two cysteine-rich LIM domains but lacks a DNA-binding domain. LIM domains may play a role in protein interactions; thus the encoded protein may regulate transcription by competitively binding to specific DNA-binding transcription factors. Alterations at this locus have been associated with acute lymphoblastic T-cell leukemia. Chromosomal rearrangements have been observed between this locus and at least two loci, the delta subunit of the T-cell antigen receptor gene and the LIM domain binding 1 gene. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2012]
UniProt Code:P25800
NCBI GenInfo Identifier:394025675
NCBI Gene ID:4004
NCBI Accession:NP_001257357.1
UniProt Secondary Accession:P25800,Q4VBC5, Q8IXR0, E9PSF5,
UniProt Related Accession:P25800
Molecular Weight:Calculated MW: 17kDaObserved MW: 14kDa
NCBI Full Name:rhombotin-1 isoform b
NCBI Synonym Full Names:LIM domain only 1 (rhombotin 1)
NCBI Official Symbol:LMO1��
NCBI Official Synonym Symbols:TTG1; RBTN1; RHOM1��
NCBI Protein Information:rhombotin-1
UniProt Protein Name:Rhombotin-1
UniProt Synonym Protein Names:Cysteine-rich protein TTG-1; LIM domain only protein 1; LMO-1; T-cell translocation protein 1
Protein Family:Rhombotin
UniProt Gene Name:LMO1��
UniProt Entry Name:RBTN1_HUMAN
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