Human LINGO1 Recombinant Protein (RPPB3866)
- SKU:
- RPPB3866
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q96FE5
Description
| Product Name: | Human LINGO1 Recombinant Protein |
| Product Code: | RPPB3866 |
| Size: | 20µg |
| Species: | Human |
| Target: | LINGO1 |
| Synonyms: | Leucine Rich Repeat And Ig Domain Containing 1, LRRN6A, Leucine-RichRepeat And Immunoglobulin Domain-Containing Protein 1, Leucine-Rich RepeatNeuronal Protein 1, Leucine Rich Repeat Neuronal 6A, LERN1, Leucine-RichRepeat And Immunoglobulin-Like Domain-Containing Nogo Receptor-InteractingProtein 1, Leucine-Rich Repeat Neuronal Protein 6A, UNQ201, LERN1, Leucine-richrepeat and immunoglobulin-like domain-containing nogo receptor-interactingprotein 1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | LINGO1 protein solution (1mg/ml) containing 20mM Tris-HClbuffer (pH 8.0) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSLKVL EISHWPYLDT MTPNCLYGLN LTSLSITHCN LTAVPYLAVRHLVYLRFLNL SYNPISTIEG SMLHELLRLQ EIQLVGGQLA VVEPYAFRGL NYL |
Leucine Rich Repeat And Ig Domain Containing 1, also known as Lingo1 isprimarily expressed in neuronal tissue, and most abundantly in the cortex. Inaddition, Lingo 1 is involved in the inhibition of axon regeneration all theway through a ternary complex formed with NgR1 (ligand-binding subunit) and p75(signal transducing subunit). The inhibitory action is accomplished throughRhoA-GTP upregulation in response to the presence of MOG, MAG or Nogo-66 in thecentral nervous system. Furthermore, LINGO-1 inhibits oligodendrocyte precursordifferentiation as well as myelination, by a mechanism which also involvesactivation of RhoA, however it appears that it does not require 75 or NgR1.
LINGO1 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 133 amino acids (241-337 a.a) andhaving a molecular mass of 15.1kDa.LINGO1 is fused to a 36 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | LINGO1: Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 15q24.3 Cellular Component: plasma membrane Molecular Function:epidermal growth factor receptor binding; protein binding Biological Process: axonogenesis; negative regulation of axonogenesis; signal transduction |
| UniProt Code: | Q96FE5 |
| NCBI GenInfo Identifier: | 50263044 |
| NCBI Gene ID: | 84894 |
| NCBI Accession: | NP_116197 |
| UniProt Secondary Accession: | Q96FE5,Q6NUK3, Q6UXM3, Q6VVG0, Q6VVG1, Q6VVG2, Q8N3K5 Q96K52, D3DW80, |
| UniProt Related Accession: | Q96FE5 |
| Molecular Weight: | 15.1kDa (133aa) |
| NCBI Full Name: | leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform a |
| NCBI Synonym Full Names: | leucine rich repeat and Ig domain containing 1 |
| NCBI Official Symbol: | LINGO1�� |
| NCBI Official Synonym Symbols: | LERN1; LRRN6A; UNQ201�� |
| NCBI Protein Information: | leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 |
| UniProt Protein Name: | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 |
| UniProt Synonym Protein Names: | Leucine-rich repeat and immunoglobulin domain-containing protein 1; Leucine-rich repeat neuronal protein 1; Leucine-rich repeat neuronal protein 6A |
| UniProt Gene Name: | LINGO1�� |
| UniProt Entry Name: | LIGO1_HUMAN |
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