Human LIN7C Recombinant Protein (RPPB3865)

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RPPB3865

Description

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Product Name:Human LIN7C Recombinant Protein
Product Code:RPPB3865
Size:20µg
Species:Human
Target:LIN7C
Synonyms:LIN-7-C, LIN-7C, MALS-3, MALS3, VELI3, Lin-7 homolog C, Protein lin-7 homolog C, Mammalian lin-seven protein 3, MALS-3, Veli-3, LIN7C, Vertebrate lin-7 homolog 3.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:LIN7C protein solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl and 30% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE
Amino Acid Sequence:MGCSHHHHHH SSGLVPRGSH MGSMAALGEP VRLERDICRA IELLEKLQRS GEVPPQKLQA LQRVLQSEFC NAVREVYEHV YETVDISSSP EVRANATAKA TVAAFAASEG HSHPRVVELP KTEEGLGFNI MGGKEQNSPI YISRIIPGGI ADRHGGLKRG DQLLSVNGVS VEGEHHEKAV ELLKAAQGKV KLVVRYTPKV LEEMESRFEK MRSAKRRQQT

LIN7C has a part in establishing and preserving the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. LIN7C forms membrane-associated multiprotein complexes which regulate distribution and recycling of proteins to the appropriate membrane domains.

LIN7C Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 220 amino acids (1-197 a.a.) and having a molecular mass of 24.2 kDa. LIN7C is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:LIN7C: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. Belongs to the lin-7 family.
UniProt Protein Details:

Protein type:Cell adhesion

Chromosomal Location of Human Ortholog: 11p14

Cellular Component: basolateral plasma membrane; cytoplasm; intercellular junction; plasma membrane

Molecular Function:cytoskeletal protein binding; protein domain specific binding

Biological Process: exocytosis; maintenance of epithelial cell polarity; morphogenesis of an epithelial sheet; neurotransmitter secretion

UniProt Code:Q9NUP9
NCBI GenInfo Identifier:59798474
NCBI Gene ID:55327
NCBI Accession:Q9NUP9.1
UniProt Related Accession:Q9NUP9
Molecular Weight:21,834 Da
NCBI Full Name:Protein lin-7 homolog C
NCBI Synonym Full Names:lin-7 homolog C, crumbs cell polarity complex component
NCBI Official Symbol:LIN7C��
NCBI Official Synonym Symbols:MALS3; VELI3; LIN-7C; MALS-3; LIN-7-C��
NCBI Protein Information:protein lin-7 homolog C
UniProt Protein Name:Protein lin-7 homolog C
UniProt Synonym Protein Names:Mammalian lin-seven protein 3; MALS-3; Vertebrate lin-7 homolog 3; Veli-3
Protein Family:Protein
UniProt Gene Name:LIN7C��
UniProt Entry Name:LIN7C_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9NUP9
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